Cynomolgus CD200/OX-2 Protein (CD2-CM120)
Catalog: CD2-CM120
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Product Description | Recombinant Cynomolgus CD200/OX-2 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Gln56-Gly257. |
Product Background |
CD200 and its receptors are highly expressed in the lung, on epithelial cells and leukocytes, and emerging evidence links dysregulation of the CD200 pathway with asthma. Moreover, pharmacological modulation of CD200 receptors was shown to improve clinical and inflammatory outcomes of preclinical asthma models. |
Product Category |
Recombinant Protein |
Target |
CD200/OX-2 |
Accession | |
Species |
Cynomolgus |
Amino Acid Range |
Gln56-Gly257 |
Molecular Weight | The protein has a predicted MW of 23.66 kDa. Due to glycosylation, the protein migrates to 45-55 kDa based on Tris-Bis PAGE result. |
Activity |
Immobilized Cynomolgus CD200, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Human CD200 R1, hFc Tag with the EC50 of 6.2ng/ml determined by ELISA (QC Test). The affinity constant of 35.84 nM as determined in SPR assay (Biacore T200). See testing image for detail. |
Product Tag |
C-His |
Express System |
HEK293 |
Purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
Endotoxin | Less than 1EU per ug by the LAL method. |
Form | Lyophilized |
Shipping | Shipped at ambient temperature. |
Formulation | Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage | Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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