Regular price
$346.50
Order by 4pm ET for delivery on:
Cynomolgus CD96/TACTILE Protein (CD9-CM196) Summary
Product Description |
Recombinant Cynomolgus CD96/TACTILE Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Val22-Gly502. |
Product Background |
The receptors CD96 and TIGIT are expressed on the surface of T and natural killer (NK) cells, and recent studies suggest both play important inhibitory roles in immune function. CD96 has been shown to modulate immune cell activity in mice, with Cd96-/- mice displaying hypersensitive NK-cell responses to immune challenge and significant tumor resistance. The counterbalance between the putative inhibitory CD96 and TIGIT receptors and the activating receptor, CD226, offers unique strategies for immuno-oncology drug development. |
Product Category |
Recombinant Protein / Antibody discovery / Immune checkpoint proteins |
Cynomolgus CD96/TACTILE Protein (CD9-CM196) Specifications/Details
Protein |
CD96/TACTILE |
Synonyms |
CD96 molecule; CD96; DKFZp667E2122; TACTILE |
Accession |
|
Species |
Cynomolgus |
Biotinylated |
no |
Amino Acid Range |
Val22-Gly502 |
Molecular Weight |
The protein has a predicted MW of 54.27 kDa. Due to glycosylation, the protein migrates to 80-130 kDa based on Bis-Tris PAGE result. |
Activity |
Immobilized Cynomolgus CD96, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Anti-CD96 Antibody, hFc Tag with the EC50 of 0.73ug/ml determined by ELISA (QC Test). |
Product Tag |
C-His |
Fluorophore |
Unconjugated |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE |
Endotoxin |
Less than 1 EU per ug by the LAL method. |
Shipping, Reconstitution, & Storage
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
Stability And Storage |
-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Validation Images
|
|
Immobilized Cynomolgus CD96, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Anti-CD96 Antibody, hFc Tag with the EC50 of 0.73ug/ml determined by ELISA (QC Test). |
|
|
Cynomolgus CD96 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
Other Available Proteins:
Finding available proteins...
Related Products
Have more questions?
Check out our Frequently Asked Questions page for more details about product specifications, ordering, and shipments.
Contact Us
Recommended Products
Loading...
Recently viewed
