Cynomolgus CDH3/Cadherin 3 Protein (CDH-CM103)

Immobilized Cynomolgus CDH3, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-CDH3 Antibody, hFc Tag with the EC50 of 5.3ng/ml determined by ELISA.

Cynomolgus CDH3 on Bis-Tris PAGE under reduced condition. The purity is greater than 90%.

Loaded Anti-CDH3 Antibody hFc Tag on ProA-Biosensor can bind Cynomolgus CDH3, His Tag with an affinity constant of 47.10 nM as determined in BLI assay.

Express System: HEK293
Product Tag: C-His
Purity: > 90% as determined by Bis-Tris PAGE
Activity: Immobilized Cynomolgus CDH3, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-CDH3 Antibody, hFc Tag with the EC50 of 5.3ng/ml determined by ELISA.
Amino Acid Range: Asp108-Gly654

Catalog #CDH-CM103

Price

$346⁵⁰

Size

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Cynomolgus CDH3/Cadherin 3 Protein (CDH-CM103) Summary

Product Description

Recombinant Cynomolgus CDH3/Cadherin 3 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Asp108-Gly654.

Product Background

Placental-Cadherin (CDH3), a cell adhesion molecule, is associated with the function of cells to bind with other cells and the extracellular matrix (ECM). CDH3 is highly expressed in many malignancies, and has been proved it could be a serum marker to monitor colorectal cancer. Inhibited CDH3 expression could upregulate E-cadherin, downregulated N-cadherin, which may control invasion and migration.

Cynomolgus CDH3/Cadherin 3 Protein (CDH-CM103) Specifications/Details

Protein	CDH3/Cadherin 3
Synonyms	Cadherin-3; Placental cadherin; P-cadherin; CDH3; CDHP; HJMD; PCAD; PCADP-cadherin; CAD3
Accession	XP_005592414.1
Species	Cynomolgus
Biotinylated	no
Amino Acid Range	Asp108-Gly654
Molecular Weight	The protein has a predicted MW of 61.11 kDa. Due to glycosylation, the protein migrates to 70-80 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Cynomolgus CDH3, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-CDH3 Antibody, hFc Tag with the EC50 of 5.3ng/ml determined by ELISA.
Product Tag	C-His
Fluorophore	Unconjugated
Expression System	HEK293
Purity	> 90% as determined by Bis-Tris PAGE
Endotoxin	Less than 1 EU per ug by the LAL method.

Shipping, Reconstitution, & Storage

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Validation Images

	Immobilized Cynomolgus CDH3, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-CDH3 Antibody, hFc Tag with the EC50 of 5.3ng/ml determined by ELISA.
	Cynomolgus CDH3 on Bis-Tris PAGE under reduced condition. The purity is greater than 90%.
	Loaded Anti-CDH3 Antibody hFc Tag on ProA-Biosensor can bind Cynomolgus CDH3, His Tag with an affinity constant of 47.10 nM as determined in BLI assay.