Cynomolgus CRTAM Protein (CRM-CM201)

Express System: HEK293
Product Tag: C-hFc
Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Activity: Immobilized Cynomolgus CRTAM, hFc Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-CRTAM Antibody, hFc Tag with the EC50 of 73.9ng/ml determined by ELISA. See testing image for detail.
Exact Sequence: Ser18-Gly287

Catalog: CRM-CM201

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Product Description	Recombinant Cynomolgus CRTAM Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Ser18-Gly287.
Product Background	Class-I Restricted T Cell-Associated Molecule (CRTAM) is a protein that is expressed after T cell activation. The interaction of CRTAM with its ligand, nectin-like 2 (Necl2), is required for the efficient production of IL-17, IL-22, and IFNγ by murine CD4 T cells, and it plays a role in optimal CD8 T and NK cell cytotoxicity. CRTAM promotes the pro-inflammatory cytokine profile; therefore, it may take part in the immunopathology of autoimmune diseases such as diabetes type 1 or colitis.
Product Category	Recombinant Protein

Target	CRTAM
Synonyms	CD355 antigen; CD355; CRTAM
Gene/Protein ID	XP_005580021.1
Species	Cynomolgus
Exact Sequence	Ser18-Gly287
Molecular Weight	The protein has a predicted MW of 56.6 kDa. Due to glycosylation, the protein migrates to 70-80 kDa based on Tris-Bis PAGE result.
Activity	Immobilized Cynomolgus CRTAM, hFc Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-CRTAM Antibody, hFc Tag with the EC50 of 73.9ng/ml determined by ELISA. See testing image for detail.
Product Tag	C-hFc
Express System	HEK293
Purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

	Immobilized Cynomolgus CRTAM, hFc Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-CRTAM Antibody, hFc Tag with the EC50 of 73.9ng/ml determined by ELISA.
	The purity of Cynomolgus CRTAM is greater than 95% as determined by SEC-HPLC.
	Cynomolgus CRTAM on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.