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Cynomolgus DR6/TNFRSF21 Protein (DR6-CM101) Summary
Product Description |
Recombinant Cynomolgus DR6/TNFRSF21 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Gln42-His349. |
Product Background |
beta-amyloid precursor protein (APP) and death receptor 6 (DR6, also known as TNFRSF21) activate a widespread caspase-dependent self-destruction program. DR6 is broadly expressed by developing neurons, and is required for normal cell body death and axonal pruning both in vivo and after trophic-factor deprivation in vitro.DR6 is activated locally by an inactive surface ligand(s) that is released in an active form after trophic-factor deprivation. |
Product Category |
Recombinant Protein / Antibody discovery / Antibody discovery | Others |
Cynomolgus DR6/TNFRSF21 Protein (DR6-CM101) Specifications/Details
Protein |
DR6/TNFRSF21 |
Synonyms |
Death receptor 6; CD358; TNFRSF21; DR6; BM-018; MGC31965 |
Accession |
|
Species |
Cynomolgus |
Biotinylated |
no |
Amino Acid Range |
Gln42-His349 |
Molecular Weight |
The protein has a predicted MW of 34.50 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Bis-Tris PAGE result. |
Activity |
Immobilized Cynomolgus DR6, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-DR6 Antibody, hFc Tag with the EC50 of 3.4ng/ml determined by ELISA. |
Product Tag |
C-His |
Fluorophore |
Unconjugated |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1 EU per ug by the LAL method. |
Shipping, Reconstitution, & Storage
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
Stability And Storage |
-20 to -80°C for 24 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Validation Images
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Immobilized Cynomolgus DR6, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-DR6 Antibody, hFc Tag with the EC50 of 3.4ng/ml determined by ELISA. |
|
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Cynomolgus DR6 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
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The purity of Cynomolgus DR6 is greater than 95% as determined by SEC-HPLC. |
Other Available Proteins:
Finding available proteins...
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