• Express System: HEK293
  • Product Tag: C-hFc (IgG1)
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Activity: Immobilized Cynomolgus EREG, hFc Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-EREG Antibody, hFc Avi Tag with the EC50 of 49.5ng/ml determined by ELISA.
  • Amino Acid Range: Val63-Leu108
Catalog #ERE-CM201
Price
Regular price $315.00
Regular price Sale price $315.00
/
Size
Avantor VWR Fisher Scientific

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Cynomolgus EREG Protein (ERE-CM201) Summary

Product Description

 Recombinant Cynomolgus EREG Protein is expressed from HEK293 with hFc (IgG1) tag at the C-terminus.It contains Val63-Leu108.

Product Background

 Epidermal growth factor receptor (EGFR) regulates many crucial cellular programs, with seven different activating ligands shaping cell signaling in distinct ways.EGFR ligands epiregulin (EREG) and epigen (EPGN) stabilize different dimeric conformations of the EGFR extracellular region. As a consequence, EREG or EPGN induce less stable EGFR dimers than EGF-making them partial agonists of EGFR dimerization. Unexpectedly, this weakened dimerization elicits more sustained EGFR signaling than seen with EGF, provoking responses in breast cancer cells associated with differentiation rather than proliferation.

Product Category

 Recombinant Protein / Antibody discovery / Antibody discovery/Others

Cynomolgus EREG Protein (ERE-CM201) Specifications/Details

Protein
 EREG
Synonyms
 Proepiregulin; EPR; Epiregulin; EREG; ER
Accession
Species
 Cynomolgus
Biotinylated
 no
Amino Acid Range
 Val63-Leu108
Molecular Weight
 The protein has a predicted MW of 31.26 kDa. Due to glycosylation, the protein migrates to 35-45 kDa based on Bis-Tris PAGE result.
Activity
 Immobilized Cynomolgus EREG, hFc Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-EREG Antibody, hFc Avi Tag with the EC50 of 49.5ng/ml determined by ELISA.
Product Tag
 C-hFc (IgG1)

Fluorophore

 Unconjugated
Expression System
 HEK293
Purity
 > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin
 Less than 0.1 EU per ug by the LAL method.

Shipping, Reconstitution, & Storage

Form
 Lyophilized
Shipping
 Shipped at ambient temperature.
Formulation
 Lyophilized from 0.22 um filtered solution in PBS, 8% trehalose (pH 7.4).
Reconstitution
 Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage
 -20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Validation Images

Immobilized Cynomolgus EREG, hFc Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-EREG Antibody, hFc Avi Tag with the EC50 of 49.5ng/ml determined by ELISA. Immobilized Cynomolgus EREG, hFc Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-EREG Antibody, hFc Avi Tag with the EC50 of 49.5ng/ml determined by ELISA.
Cynomolgus EREG on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. Cynomolgus EREG on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Cynomolgus EREG is greater than 95% as determined by SEC-HPLC. The purity of Cynomolgus EREG is greater than 95% as determined by SEC-HPLC.
Other Available Proteins:
Finding available proteins...
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