Name: Cynomolgus GITR/TNFRSF18 Protein (GTR-CM101)
Brand: KactusBio
SKU: GTR-CM101-100UG
Price: 315.0 USD
Availability: InStock

Cynomolgus GITR/TNFRSF18 Protein (GTR-CM101)

Cynomolgus GITR Ligand, His Tag immobilized on CM5 Chip can bind Cynomolgus GITR, His Tag with an affinity constant of 0.21 uM as determined in SPR assay (Biacore T200).

Immobilized Cynomolgus GITR, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-GITR Antibody, hFc Tag with the EC50 of 7.6ng/ml determined by ELISA (QC Test).

Cynomolgus GITR on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

Express System: HEK293
Product Tag: C-His
Purity: > 95% as determined by Bis-Tris PAGE
Activity: Immobilized Cynomolgus GITR, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-GITR Antibody, hFc Tag with the EC50 of 7.6ng/ml determined by ELISA (QC Test). The affinity constant of 0.21 uM as determined in SPR assay (Biacore T200). See testing image for detail.
Amino Acid Range: Gln20-Pro156

Catalog #GTR-CM101

Size

100UG

500UG

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Product Description	Recombinant Cynomolgus GITR/TNFRSF18 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Gln20-Pro156.
Product Background	GITR (glucocorticoid-induced tumor necrosis factor receptor), also known as AITR and TNFRSF18, is a 40 kDa transmembrane glycoprotein that functions in immune regulation.GIRT is a receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.
Product Category	Recombinant Protein / Antibody discovery / Immune checkpoint proteins

Protein	GITR/TNFRSF18
Synonyms	CD357; GITR; GITR-D; TNFRSF18; AITR
Accession	XP_005545180.2
Species	Cynomolgus
Biotinylated	no
Amino Acid Range	Gln20-Pro156
Molecular Weight	The protein has a predicted MW of 15.87 kDa. Due to glycosylation, the protein migrates to 25-30 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Cynomolgus GITR, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-GITR Antibody, hFc Tag with the EC50 of 7.6ng/ml determined by ELISA (QC Test). The affinity constant of 0.21 uM as determined in SPR assay (Biacore T200). See testing image for detail.
Product Tag	C-His
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Cynomolgus GITR Ligand, His Tag immobilized on CM5 Chip can bind Cynomolgus GITR, His Tag with an affinity constant of 0.21 uM as determined in SPR assay (Biacore T200).
	Immobilized Cynomolgus GITR, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-GITR Antibody, hFc Tag with the EC50 of 7.6ng/ml determined by ELISA (QC Test).
	Cynomolgus GITR on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.