Cynomolgus GPVI Protein (GP6-CM101)

  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Activity: Immobilized Cynomolgus GPVI, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-GPVI Antibody, hFc Tag with the EC50 of 5.3ng/ml determined by ELISA. See testing image for detail.
  • Exact Sequence: Gln21-Asn251

Catalog: GP6-CM101

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Product Description Recombinant Cynomolgus GPVI Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Gln21-Asn251.

Product Background

Although platelets are best known for their role in hemostasis, they are also crucial in development, host defense, inflammation, and tissue repair. Many of these roles are regulated by the immune-like receptors glycoprotein VI (GPVI) and C-type lectin receptor 2 (CLEC-2), which signal through an immunoreceptor tyrosine-based activation motif (ITAM). GPVI is activated by collagen in the subendothelial matrix, by fibrin and fibrinogen in the thrombus, and by a remarkable number of other ligands.

Product Category

Recombinant Protein

Target

GPVI

Gene/Protein ID

XP_005590417.2

Species

Cynomolgus

Exact Sequence

Gln21-Asn251
Molecular Weight The protein has a predicted MW of 26.42 kDa. Due to glycosylation, the protein migrates to 50-60 kDa based on Tris-Bis PAGE result.

Activity

Immobilized Cynomolgus GPVI, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-GPVI Antibody, hFc Tag with the EC50 of 5.3ng/ml determined by ELISA. See testing image for detail.

Product Tag

C-His

Express System

HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Immobilized Cynomolgus GPVI, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-GPVI Antibody, hFc Tag with the EC50 of 5.3ng/ml determined by ELISA.
The purity of Cynomolgus GPVI is greater than 95% as determined by SEC-HPLC.
Cynomolgus GPVI on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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