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Cynomolgus IFN alpha/beta R2 Protein, Ultra Low Endotoxin (IFN-CM1R2-UL) Summary
Product Description |
Recombinant Cynomolgus IFN alpha/beta R2 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Ile27-Lys243. |
Product Background |
Although interferon (IFN)-α is known to exert immunomodulatory and antiproliferative effects on dendritic cells (DCs) through induction of protein-coding IFN-stimulated genes (ISGs), little is known about IFN-α-regulated miRNAs in DCs. Since several miRNAs are involved in regulating DC functions, it is important to investigate whether IFN-α's effects on DCs are mediated through miRNAs as well. |
Product Category |
Recombinant Protein / Antibody discovery / Antibody discovery/Others |
Cynomolgus IFN alpha/beta R2 Protein, Ultra Low Endotoxin (IFN-CM1R2-UL) Specifications/Details
Protein |
IFN alpha/beta R2 |
Synonyms |
IFN-R-2; IFNAR2; IFNARB; IFNABR; IFN-alpha; IFN-alpha/beta R2; IFNbR2; IFN-R; β receptor 2; β receptor10; |
Accession |
|
Species |
Cynomolgus |
Biotinylated |
no |
Amino Acid Range |
Ile27-Lys243 |
Molecular Weight |
The protein has a predicted MW of 25.93 kDa. Due to glycosylation, the protein migrates to 43-60 kDa based on Bis-Tris PAGE result. |
Activity |
The affinity constant of 70.28 nM as determined in SPR assay (Biacore T200). |
Product Tag |
C-His |
Fluorophore |
Unconjugated |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 0.01 EU per ug by the LAL method. |
Shipping, Reconstitution, & Storage
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
Stability And Storage |
-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Validation Images
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Cynomolgus IFN alpha/beta R2, His Tag captured on CM5 Chip via anti-his antibody can bind Human IFN alpha 1, hFc Tag with an affinity constant of 70.28 nM as determined in SPR assay (Biacore T200). |
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Cynomolgus IFN alpha/beta R2 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
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Loaded Cynomolgus IFN alpha/beta R2, His Tag on Anti-His-Biosensor can bind Human IFN alpha 1, hFc Tag (Cat. IFN-HM2A1) with an affinity constant of 19.10 nM as determined in BLI assay. |
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The purity of Cynomolgus IFN alpha/beta R2 is greater than 95% as determined by SEC-HPLC. |
Other Available Proteins:
Finding available proteins...
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