• Express System: HEK293
  • Product Tag: No Tag
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Activity: The affinity constant of 10.68 uM as determined in SPR assay (Biacore T200).
  • Amino Acid Range: Ser113-Ala271
Catalog #IL1-CM01A
Price
Regular price $37950
Regular price Sale price $37950
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Size
Avantor VWR Fisher Scientific

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Cynomolgus IL-1 alpha/IL-1A Protein (IL1-CM01A) Summary

Product Description

 Recombinant Cynomolgus IL-1 alpha/IL-1A Protein is expressed from HEK293 without tag.It contains Ser113-Ala271.

Product Background

 The interleukin (IL)-1 family of cytokines is currently comprised of 11 members that have pleiotropic functions in inflammation and cancer. IL-1α and IL-1β were the first members of the IL-1 family to be described, and both signal via the same receptor, IL-1R. Over the last decade, much progress has been made in our understanding of biogenesis of IL-1β and its functions in human diseases.

Cynomolgus IL-1 alpha/IL-1A Protein (IL1-CM01A) Specifications/Details

Protein
 IL-1 alpha/IL-1A
Synonyms
 Interleukin-1 alpha; IL-1 alpha; Hematopoietin-1; IL1A; IL1F1; IL-1 ALPHA; IL1α; IL-1A; IL1;IL1 alpha;Interleukin-1; Interleukin 1
Accession
Species
 Cynomolgus
Biotinylated
 no
Amino Acid Range
 Ser113-Ala271
Molecular Weight
 The protein has a predicted MW of 18.13 kDa. Due to glycosylation, the protein migrates to 26-33 kDa based on Bis-Tris PAGE result.
Activity
 The affinity constant of 10.68 uM as determined in SPR assay (Biacore T200).
Product Tag
 No Tag
Fluorophore
 Unconjugated
Expression System
 HEK293
Purity
 > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin
 Less than 1 EU per ug by the LAL method.

Shipping, Reconstitution, & Storage

Form
 Liquid
Shipping
 Shipped with dry ice.
Formulation
 Supplied as 0.22 um filtered solution in PBS (pH 7.4).
Stability And Storage
 Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Validation Images

Human IL-1R1, His Tag immobilized on CM5 Chip can bind Cynomolgus IL-1 alpha, No Tag with an affinity constant of 10.68 uM as determined in SPR assay (Biacore T200). Human IL-1R1, His Tag immobilized on CM5 Chip can bind Cynomolgus IL-1 alpha, No Tag with an affinity constant of 10.68 uM as determined in SPR assay (Biacore T200).
Cynomolgus IL-1 alpha on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. Cynomolgus IL-1 alpha on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Cynomolgus IL-1 alpha is greater than 95% as determined by SEC-HPLC. The purity of Cynomolgus IL-1 alpha is greater than 95% as determined by SEC-HPLC.
Other Available Proteins:
Finding available proteins...