Product Description |
Recombinant Cynomolgus IL-1 alpha/IL-1A Protein is expressed from HEK293 without tag.It contains Ser113-Ala271. |
Product Background |
The interleukin (IL)-1 family of cytokines is currently comprised of 11 members that have pleiotropic functions in inflammation and cancer. IL-1α and IL-1β were the first members of the IL-1 family to be described, and both signal via the same receptor, IL-1R. Over the last decade, much progress has been made in our understanding of biogenesis of IL-1β and its functions in human diseases. |
Product Category |
Recombinant Protein |
Target |
IL-1 alpha/IL-1A |
Synonyms |
Interleukin-1 alpha; IL-1 alpha; Hematopoietin-1; IL1A; IL1F1; IL-1 ALPHA; IL1α; IL-1A; IL1 |
Accession |
|
Species |
Cynomolgus |
Biotinylated |
no |
Amino Acid Range |
Ser113-Ala271 |
Molecular Weight |
The protein has a predicted MW of 18.13 kDa. Due to glycosylation, the protein migrates to 26-33 kDa based on Bis-Tris PAGE result. |
Activity |
The affinity constant of 10.68 uM as determined in SPR assay (Biacore T200). See testing image for detail. |
Product Tag |
No Tag |
Express System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage |
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
|
|
Human IL-1R1, His Tag immobilized on CM5 Chip can bind Cynomolgus IL-1 alpha, No Tag with an affinity constant of 10.68 uM as determined in SPR assay (Biacore T200). |
|
|
Cynomolgus IL-1 alpha on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
|
|
The purity of Cynomolgus IL-1 alpha is greater than 95% as determined by SEC-HPLC. |
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