Name: Cynomolgus IL-10 R alpha Protein (IL1-CM1RA)
Brand: KactusBio
SKU: IL1-CM1RA-100UG
Price: 315.0 USD
Availability: InStock

Cynomolgus IL-10 R alpha Protein (IL1-CM1RA)

Cynomolgus IL-10 R alpha, His Tag immobilized on CM5 Chip can bind Cynomolgus IL-10, His Tag with an affinity constant of 0.93 nM as determined in SPR assay (Biacore T200).

Immobilized Human IL-10, No Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Cynomolgus IL-10 R alpha, His Tag with the EC50 of 2.4ng/ml determined by ELISA (QC Test).

Cynomolgus IL-10 R alpha on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

The purity of Cynomolgus IL-10 R alpha is greater than 95% as determined by SEC-HPLC.

Express System: HEK293
Product Tag: C-His
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: Immobilized Human IL-10, No Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Cynomolgus IL-10 R alpha, His Tag with the EC50 of 2.4ng/ml determined by ELISA (QC Test). The affinity constant of 0.93 nM as determined in SPR assay (Biacore T200). See testing image for detail.
Amino Acid Range: His22-Asn233

Catalog #IL1-CM1RA

Size

100UG

500UG

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Product Description	Recombinant Cynomolgus IL-10 R alpha Protein is expressed from HEK293 with His tag at the C-Terminus.It contains His22-Asn233.
Product Background	The interleukin-10 receptor alpha (IL10RA) gene codes for the alpha chain of the IL-10 receptor which binds the cytokine IL-10. IL-10 is an anti-inflammatory cytokine with immunoregulatory function during the pathogenesis of many inflammatory disorders in livestock, including Johne's disease (JD). JD is a chronic enteritis in cattle caused by Mycobacterium avium subsp. paratuberculosis (MAP) and is responsible for significant economic losses to the dairy industry. Several candidate genes including IL10RA have been found to be associated with JD.
Product Category	Recombinant Protein / Antibody discovery

Protein	IL-10 R alpha
Synonyms	IL-10RA; IL10RA; IL10R; IL-10R1; IL-10R subunit 1; CDw210a; HIL-10R; IBD28; IL-10 R alpha
Accession	A0A2K5WJ66
Species	Cynomolgus
Biotinylated	no
Amino Acid Range	His22-Asn233
Molecular Weight	The protein has a predicted MW of 25.34 kDa. Due to glycosylation, the protein migrates to 45-60 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Human IL-10, No Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Cynomolgus IL-10 R alpha, His Tag with the EC50 of 2.4ng/ml determined by ELISA (QC Test). The affinity constant of 0.93 nM as determined in SPR assay (Biacore T200). See testing image for detail.
Product Tag	C-His
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Cynomolgus IL-10 R alpha, His Tag immobilized on CM5 Chip can bind Cynomolgus IL-10, His Tag with an affinity constant of 0.93 nM as determined in SPR assay (Biacore T200).
	Immobilized Human IL-10, No Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Cynomolgus IL-10 R alpha, His Tag with the EC50 of 2.4ng/ml determined by ELISA (QC Test).
	Cynomolgus IL-10 R alpha on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Cynomolgus IL-10 R alpha is greater than 95% as determined by SEC-HPLC.