Cynomolgus IL-11 Protein, Ultra Low Endotoxin (IL1-CM111-UL)
  • Express System: HEK293
  • Product Tag: N-His
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Activity: The affinity constant of 0.25 nM as determined in SPR assay (Biacore T200). See testing image for detail.
  • Amino Acid Range: Pro22-Leu199
Catalog #IL1-CM111-UL
Regular price $381.00
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Product Description

Recombinant Cynomolgus IL-11 Protein is expressed from HEK293 with His tag at the N-Terminus.It contains Pro22-Leu199.

Product Background

Abstract Interleukin-11 (IL-11) is a pleiotropic cytokine that belongs to gp130 family. IL-11 and its receptor, IL-11Ra, are expressed in human cancers,human cancer cells expressed a functional IL-11Ra subunit, which triggered signal transduction either by exogenous recombinant human IL-11 or by autocrine production of IL-11 in cells cultured under hypoxic conditions.

Product Category

Recombinant Protein / Antibody discovery / Antibody discovery | Others

Protein

IL-11

Synonyms

Interleukin-11;IL11;Adipogenesis inhibitory factor;AGIF;INN: Oprelvekin;Oprelvekin;IL-11Oprelvekin;interleukin 11;interleukin-11

Accession

Species

Cynomolgus

Biotinylated

no

Amino Acid Range

Pro22-Leu199

Molecular Weight

The protein has a predicted MW of 20.48 kDa. Due to glycosylation, the protein migrates to 21-25 kDa based on Bis-Tris PAGE result.

Activity

The affinity constant of 0.25 nM as determined in SPR assay (Biacore T200). See testing image for detail.

Product Tag

N-His

Expression System

HEK293

Purity

> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC

Endotoxin

Less than 0.01 EU per ug by the LAL method.
Form
Lyophilized
Shipping
Shipped at ambient temperature.
Formulation
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage
-20 to -80°C for 12 months as supplied from date of receipt.;-80°C for 3 months after reconstitution.;Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Human IL-11 R alpha, hFc Tag captured on CM5 Chip via Protein A can bind Cynomolgus IL-11, His Tag with an affinity constant of 0.25 nM as determined in SPR assay (Biacore T200). Human IL-11 R alpha, hFc Tag captured on CM5 Chip via Protein A can bind Cynomolgus IL-11, His Tag with an affinity constant of 0.25 nM as determined in SPR assay (Biacore T200).
Cynomolgus IL-11 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. Cynomolgus IL-11 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Cynomolgus IL-11 is greater than 95% as determined by SEC-HPLC. The purity of Cynomolgus IL-11 is greater than 95% as determined by SEC-HPLC.

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