Name: Cynomolgus IL-12B/p40/NKSF2 Protein (P40-CM112)
Brand: KactusBio
SKU: P40-CM112-100UG
Price: 375.0 USD
Availability: InStock

Cynomolgus IL-12B/p40/NKSF2 Protein (P40-CM112)

Immobilized Cynomolgus IL-12B, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-IL-12 Antibody, hFc Tag with the EC50 of 2.3ng/ml determined by ELISA (QC Test).

Cynomolgus IL-12B on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

The purity of Cynomolgus IL-12B is greater than 95% as determined by SEC-HPLC.

Express System: HEK293
Product Tag: C-His
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: Immobilized Cynomolgus IL-12B, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-IL-12 Antibody, hFc Tag with the EC50 of 2.3ng/ml determined by ELISA (QC Test). See testing image for detail.
Amino Acid Range: Ile23-Ser328

Catalog #P40-CM112

Size

100UG

500UG

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Product Description	Recombinant Cynomolgus IL-12B/p40/NKSF2 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Ile23-Ser328.
Product Background	Interleukin (IL)‑12B, which encodes the p40 subunit common to IL‑12 and IL‑23, as one of the genes for which expression in fibroblast‑like synoviocytes from patients with rheumatoid arthritis (RA‑FLS) is induced by DcR3.Decoy receptor 3 (DcR3) competitively binds to three ligands, Fas ligand, lymphotoxin‑related inducible ligand that competes for glycoprotein D binding to herpesvirus entry mediator on T cells and tumor necrosis factor‑like ligand 1A (TL1A), to prevent their effects. Recent studies have suggested that DcR3 directly affects cells as a ligand.
Product Category	Recombinant Protein / Antibody discovery

Protein	IL-12B/p40/NKSF2
Synonyms	IL-12B; CLMF p40; IL-12 subunit p40; NKSF2; CLMF; CLMF2; NKS
Accession	A0A2K5TM36
Species	Cynomolgus
Biotinylated	no
Amino Acid Range	Ile23-Ser328
Molecular Weight	The protein has a predicted MW of 35.86 kDa. Due to glycosylation, the protein migrates to 40-50 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Cynomolgus IL-12B, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-IL-12 Antibody, hFc Tag with the EC50 of 2.3ng/ml determined by ELISA (QC Test). See testing image for detail.
Product Tag	C-His
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Immobilized Cynomolgus IL-12B, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-IL-12 Antibody, hFc Tag with the EC50 of 2.3ng/ml determined by ELISA (QC Test).
	Cynomolgus IL-12B on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Cynomolgus IL-12B is greater than 95% as determined by SEC-HPLC.