Cynomolgus IL-13 Protein (IL1-CM113)

  • Express System: HEK293
  • Product Tag: N-His
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Activity: The affinity constant of 21.16 nM as determined in SPR assay (Biacore T200). See testing image for detail.
  • Exact Sequence: Ser19-Asn132

Catalog: IL1-CM113

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Product Description Recombinant Cynomolgus IL-13 Protein is expressed from HEK293 with His tag at the N-Terminus.It contains Ser19-Asn132.

Product Background

Interleukin-13 (IL-13) is a monomeric 17 kDa immunoregulatory cytokine that plays a key role in the pathogenesis of allergy, cancer, and tissue fibrosis. It is secreted by several helper T cell subsets, NK cells, mast cells, eosinophils, basophils, and visceral smooth muscle cells. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages.

Product Category

Recombinant Protein

Target

IL-13

Gene/Protein ID

Q0PW92

Species

Cynomolgus

Exact Sequence

Ser19-Asn132
Molecular Weight The protein has a predicted MW of 13.59 kDa. Due to glycosylation, the protein migrates to 30-45 kDa based on Tris-Bis PAGE result.

Activity

The affinity constant of 21.16 nM as determined in SPR assay (Biacore T200). See testing image for detail.

Product Tag

N-His

Express System

HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Cynomolgus IL-13Ra1,His Tag immobilized on CM5 Chip can bind Cynomolgus IL-13, His Tag with an affinity constant of 21.16 nM as determined in SPR assay (Biacore T200).
The purity of Cynomolgus IL-13 is greater than 95% as determined by SEC-HPLC.
Cynomolgus IL-13 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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