Cynomolgus IL-13 Protein (IL1-CM113)
Catalog: IL1-CM113
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Product Description | Recombinant Cynomolgus IL-13 Protein is expressed from HEK293 with His tag at the N-Terminus.It contains Ser19-Asn132. |
Product Background |
Interleukin-13 (IL-13) is a monomeric 17 kDa immunoregulatory cytokine that plays a key role in the pathogenesis of allergy, cancer, and tissue fibrosis. It is secreted by several helper T cell subsets, NK cells, mast cells, eosinophils, basophils, and visceral smooth muscle cells. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages. |
Product Category |
Recombinant Protein |
Target |
IL-13 |
Accession | |
Species |
Cynomolgus |
Amino Acid Range |
Ser19-Asn132 |
Molecular Weight | The protein has a predicted MW of 13.59 kDa. Due to glycosylation, the protein migrates to 30-45 kDa based on Tris-Bis PAGE result. |
Activity |
Immobilized Cynomolgus IL-13, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human IL-13Ra2, hFc Tag with the EC50 of 1.72ug/ml determined by ELISA (QC Test). The affinity constant of 21.16 nM as determined in SPR assay (Biacore T200). See testing image for detail. |
Product Tag |
N-His |
Express System |
HEK293 |
Purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
Endotoxin | Less than 1EU per ug by the LAL method. |
Form | Lyophilized |
Shipping | Shipped at ambient temperature. |
Formulation | Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage | Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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