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Cynomolgus IL-1R3/IL-1 RAcP Protein (ILR-CM1R3) Summary
Product Description |
Recombinant Cynomolgus IL-1R3/IL-1 RAcP Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Ser21-Cys362. |
Product Background |
IL-1 Receptor Accessory Protein (IL-1 RAcP), also known as IL-1 R3, is a ubiquitously expressed 70-90 kDa member of the Interleukin-1 receptor family of proteins. It serves as a non-ligand-binding component of the receptors for IL-1 alpha, IL-1 beta, IL-33, and IL-36. IL-1 R3 is a coreceptor for IL1RL2 in the IL-36 signaling system. IL-1 R3 is a coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. |
Product Category |
Recombinant Protein / Antibody discovery / ADC targets |
Cynomolgus IL-1R3/IL-1 RAcP Protein (ILR-CM1R3) Specifications/Details
Protein |
IL-1R3/IL-1 RAcP |
Synonyms |
IL1RAP; IL-1RAP; C3orf13; IL-1 R3; IL-1 RAcP |
Accession |
|
Species |
Cynomolgus |
Biotinylated |
no |
Amino Acid Range |
Ser21-Cys362 |
Molecular Weight |
The protein has a predicted MW of 40.49 kDa. Due to glycosylation, the protein migrates to 55-70 kDa based on Bis-Tris PAGE result. |
Activity |
Immobilized Cynomolgus IL-1R3, His Tag at 0.5 ug/ml (100 ul/well) on the plate. Dose response curve for Anti-IL-1R3 Antibody, hFc Tag with the EC50 of 2.6 ng/ml determined by ELISA (QC Test). |
Product Tag |
C-His |
Fluorophore |
Unconjugated |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1 EU per ug by the LAL method. |
Shipping, Reconstitution, & Storage
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
Stability And Storage |
-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Validation Images
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Immobilized Cynomolgus IL-1R3, His Tag at 0.5 ug/ml (100 ul/well) on the plate. Dose response curve for Anti-IL-1R3 Antibody, hFc Tag with the EC50 of 2.6 ng/ml determined by ELISA (QC Test). |
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Cynomolgus IL-1R3 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
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The purity of Cynomolgus IL-1R3 is greater than 95% as determined by SEC-HPLC. |
Other Available Proteins:
Finding available proteins...
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