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Cynomolgus IL-2 R alpha/CD25 Protein (CD5-CM125) Summary
Product Description |
Recombinant Cynomolgus IL-2 R alpha/CD25 Protein is expressed from HEK293 with His tag at the C-terminus.It contains Glu22-Glu238. |
Product Background |
IL-2 receptor alpha (IL-2 R alpha), also known as Tac antigen and as CD25, was initially identified as a 55 kDa membrane glycoprotein that is capable of binding IL‑2.eceptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. |
Product Category |
Recombinant Protein / Antibody discovery / ADC targets |
Cynomolgus IL-2 R alpha/CD25 Protein (CD5-CM125) Specifications/Details
Protein |
IL-2 R alpha/CD25 |
Synonyms |
CD25; IDDM10; IL-2 R alpha; IL2R; IL2RA; p55; TCGFR |
Accession |
|
Species |
Cynomolgus |
Biotinylated |
no |
Amino Acid Range |
Glu22-Glu238 |
Molecular Weight |
The protein has a predicted MW of 69.61 kDa. Due to glycosylation, the protein migrates to 55-70 kDa based on Bis-Tris PAGE result. |
Activity |
Immobilized Cynomolgus IL-2 R alpha, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Human IL-2, His Avi Tag (Cat. IL2-HM401B) with the EC50 of 0.15ug/ml determined by ELISA. |
Product Tag |
C-His |
Fluorophore |
Unconjugated |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 0.1 EU per ug by the LAL method. |
Shipping, Reconstitution, & Storage
Form |
Liquid |
Shipping |
Shipped with dry ice. |
Formulation |
Supplied as 0.22 um filtered solution in PBS (pH 7.4). |
Stability And Storage |
Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Validation Images
|
|
Immobilized Cynomolgus IL-2 R alpha, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Human IL-2, His Avi Tag (Cat. IL2-HM401B) with the EC50 of 0.15ug/ml determined by ELISA. |
|
|
Cynomolgus IL-2 R alpha on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
|
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The purity of Cynomolgus IL-2 R alpha is greater than 95% as determined by SEC-HPLC. |
Other Available Proteins:
Finding available proteins...
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