Name: Cynomolgus IL-23 alpha&IL-12 beta Protein (IL2-CM123)
Brand: KactusBio
SKU: IL2-CM123-100UG
Price: 473.0 USD
Availability: InStock

Cynomolgus IL-23 alpha&IL-12 beta Protein (IL2-CM123)

Human IL-23R, hFc Tag captured on CM5 Chip via Protein A can bind Cynomolgus IL-23 alpha&IL-12 beta, His Tag with an affinity constant of 4.05 nM as determined in SPR assay (Biacore T200).

Immobilized Cynomolgus IL-23 alpha&IL-12 beta, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human IL-23R, hFc Tag with the EC50 of 0.17ug/ml determined by ELISA (QC Test).

Cynomolgus IL-23 alpha&IL-12 beta on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

The purity of Cynomolgus IL-23 alpha&IL-12 beta is greater than 95% as determined by SEC-HPLC.

Express System: HEK293
Product Tag: N-His
Purity: >95% as determined by Bis-Tris PAGE;>95% as determined by HPLC
Activity: Immobilized Cynomolgus IL-23 alpha&IL-12 beta, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human IL-23R, hFc Tag with the EC50 of 0.17ug/ml determined by ELISA (QC Test). The affinity constant of 4.05 nM as determined in SPR assay (Biacore T200). See testing image for detail.
Amino Acid Range: Val22-Pro189(IL-23 alpha) & Ile23-Ser328(IL-12 beta)

Catalog #IL2-CM123

Size

100UG

500UG

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Product Description	Recombinant Cynomolgus IL-23 alpha&IL-12 beta Protein is expressed from HEK293 with His tag at the N-terminus.It contains Val22-Pro189(IL-23 alpha) & Ile23-Ser328(IL-12 beta).
Product Background	The interleukin (IL)-12 family of cytokines, including IL12 and IL 23, play an important role in driving aberrant Th1 and Th17 immune responses in patients with Crohn's disease (CD). Targeting this pathway has opened new avenues for therapeutic intervention. The balance of proinflammatory cytokines interleukin (IL)-12 and IL-23 plays a key role in shaping the development of antitumor or protumor immunity.
Product Category	Recombinant Protein / Antibody discovery

Protein	IL-23 alpha&IL-12 beta
Synonyms	IL23 alpha; IL12 beta; IL23 alpha&IL12 beta ; IL12 β; IL23 alpha&IL12 β
Accession	G7PIH8(IL-23 alpha)&XP_045250400.1(IL-12 beta)
Species	Cynomolgus
Biotinylated	no
Amino Acid Range	Val22-Pro189(IL-23 alpha) & Ile23-Ser328(IL-12 beta)
Molecular Weight	The protein has a predicted MW of 19.52 kDa (IL-23 alpha) and 34.76 kDa (IL-12 beta). Due to glycosylation, the protein migrates to 20-25 kDa (IL-23 alpha) and 40-50 kDa (IL-12 beta) based on Bis-Tris PAGE result.
Activity	Immobilized Cynomolgus IL-23 alpha&IL-12 beta, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human IL-23R, hFc Tag with the EC50 of 0.17ug/ml determined by ELISA (QC Test). The affinity constant of 4.05 nM as determined in SPR assay (Biacore T200). See testing image for detail.
Product Tag	N-His
Expression System	HEK293
Purity	>95% as determined by Bis-Tris PAGE;>95% as determined by HPLC
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Human IL-23R, hFc Tag captured on CM5 Chip via Protein A can bind Cynomolgus IL-23 alpha&IL-12 beta, His Tag with an affinity constant of 4.05 nM as determined in SPR assay (Biacore T200).
	Immobilized Cynomolgus IL-23 alpha&IL-12 beta, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human IL-23R, hFc Tag with the EC50 of 0.17ug/ml determined by ELISA (QC Test).
	Cynomolgus IL-23 alpha&IL-12 beta on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Cynomolgus IL-23 alpha&IL-12 beta is greater than 95% as determined by SEC-HPLC.