Cynomolgus IL-23 alpha&IL-12 beta Protein (IL2-CM123)
  • Express System: HEK293
  • Product Tag: N-His
  • Purity: >95% as determined by Bis-Tris PAGE;>95% as determined by HPLC
  • Activity: Immobilized Cynomolgus IL-23 alpha&IL-12 beta, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human IL-23R, hFc Tag with the EC50 of 0.11ug/ml determined by ELISA (QC Test). See testing image for detail.
  • Amino Acid Range: Val22-Pro189(IL-23 alpha) & Pro23-Leu328(IL-12 beta)
Catalog #IL2-CM123
/
Size

Order now, ships by:

Product Description
 Recombinant Cynomolgus IL-23 alpha&IL-12 beta Protein is expressed from HEK293 with His tag at the N-terminus.It contains Val22-Pro189(IL-23 alpha) & Pro23-Leu328(IL-12 beta).
Product Background
 The interleukin (IL)-12 family of cytokines, including IL12 and IL 23, play an important role in driving aberrant Th1 and Th17 immune responses in patients with Crohn's disease (CD). Targeting this pathway has opened new avenues for therapeutic intervention. The balance of proinflammatory cytokines interleukin (IL)-12 and IL-23 plays a key role in shaping the development of antitumor or protumor immunity.
Product Category
 Recombinant Protein
Target
 IL-23 alpha&IL-12 beta
Accession
Species
 Cynomolgus
Biotinylated
 no
Amino Acid Range
 Val22-Pro189(IL-23 alpha) & Pro23-Leu328(IL-12 beta)
Molecular Weight
 The protein has a predicted MW of 19.52 kDa (IL-23 alpha) and 34.76 kDa (IL-12 beta). Due to glycosylation, the protein migrates to 20-25 kDa (IL-23 alpha) and 40-50 kDa (IL-12 beta) based on Bis-Tris PAGE result.
Activity
 Immobilized Cynomolgus IL-23 alpha&IL-12 beta, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human IL-23R, hFc Tag with the EC50 of 0.11ug/ml determined by ELISA (QC Test). See testing image for detail.
Product Tag
 N-His
Express System
 HEK293
Purity
 >95% as determined by Bis-Tris PAGE;>95% as determined by HPLC
Endotoxin
 Less than 1EU per ug by the LAL method.
Form
 Liquid
Shipping
 Shipped with dry ice.
Formulation
 Supplied as 0.22 um filtered solution in PBS (pH 7.4).
Stability And Storage
 Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Immobilized Cynomolgus IL-23 alpha&IL-12 beta, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human IL-23R, hFc Tag with the EC50 of 0.11ug/ml determined by ELISA (QC Test).
Cynomolgus IL-23 alpha&IL-12 beta on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Cynomolgus IL-23 alpha&IL-12 beta is greater than 95% as determined by SEC-HPLC.
Recently viewed