Name: Cynomolgus IL-31 RA Protein (ILR-CM1RA)
Brand: KactusBio
SKU: ILR-CM1RA-100UG
Price: 450.0 USD
Availability: InStock

Express System: HEK293
Product Tag: C-His
Purity: > 95% as determined by Bis-Tris PAGE;> 85% as determined by HPLC
Activity: Immobilized Cynomolgus IL-31RA, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-IL-31 RA Antibody, hFc Tag with the EC50 of 3.3ng/ml determined by ELISA. The affinity constant of 6.83 nM as determined in SPR assay (Biacore T200).
Amino Acid Range: Ala20-Glu519

Catalog #ILR-CM1RA

Size

100UG

500UG

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Cynomolgus IL-31 RA Protein (ILR-CM1RA) Summary

Product Description	Recombinant Cynomolgus IL-31 RA-Protein is expressed from HEK293 with His tag at the C-terminus.It contains Ala20-Glu519.
Product Background	Interleukin-31 receptor A (IL-31RA) is a newly identified type I cytokine receptor, that is related to gp130, the common receptor of the interleukin (IL) -6 family cytokines. IL-31RA forms a functional receptor complex for IL-31 together with the beta subunit of oncostatin M receptor (OSMR beta). OSMR beta is expressed in a subset of small-sized nociceptive neurons of adult dorsal root ganglia (DRGs). IL-31 and OSM may thus have redundant functions in the development of OSMRbeta-expressing neurons.
Product Category	Recombinant Protein / Antibody discovery / Antibody discovery/Others

Cynomolgus IL-31 RA Protein (ILR-CM1RA) Specifications/Details

Protein	IL-31 RA
Synonyms	IL-31RA; IL-31R-alpha; Gp130-like receptor; CRL3; GPL; ZcytoR17; GLM-R; CRL3Glmr
Accession	XP_045249656.2
Species	Cynomolgus
Biotinylated	no
Amino Acid Range	Ala20-Glu519
Molecular Weight	The protein has a predicted MW of 58.67 kDa. Due to glycosylation, the protein migrates to 90-120 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Cynomolgus IL-31RA, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-IL-31 RA Antibody, hFc Tag with the EC50 of 3.3ng/ml determined by ELISA. The affinity constant of 6.83 nM as determined in SPR assay (Biacore T200).
Product Tag	C-His
Fluorophore	Unconjugated
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 85% as determined by HPLC
Endotoxin	Less than 1 EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Cynomolgus IL-31, His Tag immobilized on CM5 Chip can bind Cynomolgus IL-31 RA, His Tag with an affinity constant of 6.83 nM as determined in SPR assay (Biacore T200).
	Immobilized Cynomolgus IL-31RA, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-IL-31 RA Antibody, hFc Tag with the EC50 of 3.3ng/ml determined by ELISA.
	Cynomolgus IL-31 RA on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Cynomolgus IL-31 RA is greater than 85% as determined by SEC-HPLC.

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