Name: Cynomolgus IL-31 RA Protein (ILR-CM1RA)
Brand: KactusBio
SKU: ILR-CM1RA-100UG
Price: 450.0 USD
Availability: InStock

Express System: HEK293
Product Tag: C-His
Purity: > 95% as determined by Bis-Tris PAGE;> 85% as determined by HPLC
Activity: Immobilized Cynomolgus IL-31RA, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-IL-31 RA Antibody, hFc Tag with the EC50 of 3.3ng/ml determined by ELISA. The affinity constant of 6.83 nM as determined in SPR assay (Biacore T200).
Amino Acid Range: Ala20-Glu519

Catalog #ILR-CM1RA

Size

100UG

500UG

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Cynomolgus IL-31 RA Protein (ILR-CM1RA) Summary

Product Description	Recombinant Cynomolgus IL-31 RA-Protein is expressed from HEK293 with His tag at the C-terminus.It contains Ala20-Glu519.
Product Background	Interleukin-31 receptor A (IL-31RA) is a newly identified type I cytokine receptor, that is related to gp130, the common receptor of the interleukin (IL) -6 family cytokines. IL-31RA forms a functional receptor complex for IL-31 together with the beta subunit of oncostatin M receptor (OSMR beta). OSMR beta is expressed in a subset of small-sized nociceptive neurons of adult dorsal root ganglia (DRGs). IL-31 and OSM may thus have redundant functions in the development of OSMRbeta-expressing neurons.
Product Category	Recombinant Protein / Antibody discovery / Antibody discovery \| Others

Cynomolgus IL-31 RA Protein (ILR-CM1RA) Specifications/Details

Protein	IL-31 RA
Synonyms	IL-31RA; IL-31R-alpha; Gp130-like receptor; CRL3; GPL; ZcytoR17; GLM-R; CRL3Glmr
Accession	XP_045249656.2
Species	Cynomolgus
Biotinylated	no
Amino Acid Range	Ala20-Glu519
Molecular Weight	The protein has a predicted MW of 58.67 kDa. Due to glycosylation, the protein migrates to 90-120 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Cynomolgus IL-31RA, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-IL-31 RA Antibody, hFc Tag with the EC50 of 3.3ng/ml determined by ELISA. The affinity constant of 6.83 nM as determined in SPR assay (Biacore T200).
Product Tag	C-His
Fluorophore	Unconjugated
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 85% as determined by HPLC
Endotoxin	Less than 1 EU per ug by the LAL method.

Form	Liquid
Shipping	Shipped with dry ice.
Formulation	Supplied as 0.22 um filtered solution in PBS (pH 7.4).
Stability And Storage	Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Cynomolgus IL-31, His Tag immobilized on CM5 Chip can bind Cynomolgus IL-31 RA, His Tag with an affinity constant of 6.83 nM as determined in SPR assay (Biacore T200).
	Immobilized Cynomolgus IL-31RA, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-IL-31 RA Antibody, hFc Tag with the EC50 of 3.3ng/ml determined by ELISA.
	Cynomolgus IL-31 RA on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Cynomolgus IL-31 RA is greater than 85% as determined by SEC-HPLC.

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