Cynomolgus Integrin alpha 2 beta 1 (ITGA2&ITGB1) Heterodimer Protein (ITG-CM1AB)
Catalog: ITG-CM1AB
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Product Description | Recombinant Cynomolgus Integrin alpha 2 beta 1 (ITGA2&ITGB1) Heterodimer Protein is expressed from HEK293 with His tag at the C-terminus.It contains Tyr30-Pro1130 (ITGA2) acidic tail and Gln161-Asp868 (ITGB1) basic tail. |
Product Background |
The α2β1 integrin, also known as VLA-2, GPIa-IIa, CD49b, was first identified as an extracellular matrix receptor for collagens and/or laminins. It is now recognized that the α2β1 integrin serves as a receptor for many matrix and nonmatrix molecules. It plays a critical role in platelet function and homeostasis. |
Product Category |
Recombinant Protein |
Target |
Integrin alpha 2 beta 1 (ITGA2&ITGB1) Heterodimer |
Accession | |
Species |
Cynomolgus |
Amino Acid Range |
Tyr30-Pro1130(ITGA2) acidic tail & Gln161-Asp868(ITGB1) basic tail |
Molecular Weight | The protein has a predicted MW of 126.69 kDa (ITGA2) and 83.16 kDa (ITGB1). Due to glycosylation, the protein migrates to 130-170 kDa (ITGA2) and 100-130 kDa (ITGB1) based on Tris-Bis PAGE result. |
Product Tag |
C-His |
Express System |
HEK293 |
Purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
Endotoxin | Less than 1EU per ug by the LAL method. |
Form | Lyophilized |
Shipping | Shipped at ambient temperature. |
Formulation | Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage | Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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