Name: Cynomolgus Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein (ITG-CM147)
Brand: KactusBio
SKU: ITG-CM147-100UG
Price: 462.0 USD
Availability: InStock

Cynomolgus Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein (ITG-CM147)

Immobilized Cynomolgus ITGA4&ITGB7, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Anti-ITGA4 Antibody, hFc Tag with the EC50 of 16.7ng/ml determined by ELISA.

Cynomolgus ITGA4&ITGB7 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

Loaded Anti-ITGA4 Antibody, hFc Tag on ProA-Biosensor can bind Cynomolgus ITGA4&ITGB7, His Tag with an affinity constant of 17.80 nM as determined in BLI assay (Gator® Prime).

Express System: HEK293
Product Tag: C-His
Purity: > 95% as determined by Bis-Tris PAGE
Activity: Immobilized Cynomolgus ITGA4&ITGB7, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Anti-ITGA4 Antibody, hFc Tag with the EC50 of 16.7ng/ml determined by ELISA.
Amino Acid Range: Tyr34-Thr977(ITGA4) acidic tail & Glu20-His723(ITGB7) basic tail

Catalog #ITG-CM147

Size

100UG

500UG

Order by 4pm ET for delivery on:

[{"id":46991588753630,"title":"100UG","option1":"100UG","option2":null,"option3":null,"sku":"ITG-CM147-100UG","requires_shipping":true,"taxable":true,"featured_image":null,"available":true,"name":"Cynomolgus Integrin alpha 4 beta 7 (ITGA4\u0026ITGB7) Heterodimer Protein (ITG-CM147) - 100UG","public_title":"100UG","options":["100UG"],"price":46200,"weight":5,"compare_at_price":null,"inventory_management":"shopify","barcode":null,"requires_selling_plan":false,"selling_plan_allocations":[],"quantity_rule":{"min":1,"max":null,"increment":1}},{"id":46991675162846,"title":"500UG","option1":"500UG","option2":null,"option3":null,"sku":"ITG-CM147-500UG","requires_shipping":true,"taxable":true,"featured_image":null,"available":true,"name":"Cynomolgus Integrin alpha 4 beta 7 (ITGA4\u0026ITGB7) Heterodimer Protein (ITG-CM147) - 500UG","public_title":"500UG","options":["500UG"],"price":154000,"weight":5,"compare_at_price":null,"inventory_management":"shopify","barcode":null,"requires_selling_plan":false,"selling_plan_allocations":[],"quantity_rule":{"min":1,"max":null,"increment":1}}]

Cynomolgus Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein (ITG-CM147) Summary

Product Description	Recombinant Cynomolgus Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein is expressed from HEK293 with His tag at the C-terminus.It contains Tyr34-Thr977 (ITGA4) acidic tail and Glu20-His723 (ITGB7) basic tail.
Product Background	Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1.
Product Category	Recombinant Protein / Antibody discovery / Antibody discovery \| Others

Cynomolgus Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein (ITG-CM147) Specifications/Details

Protein	Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer
Synonyms	Integrin alpha 4 beta 7; beta7; alpha 4; LPAM; ITGA4&ITGB7;Integrin alpha 4 β 7; β7
Accession	XP_005573683.3(ITGA4)&XP_005571028.3(ITGB7)
Species	Cynomolgus
Biotinylated	no
Amino Acid Range	Tyr34-Thr977(ITGA4) acidic tail & Glu20-His723(ITGB7) basic tail
Molecular Weight	The protein has a predicted MW of 110.87 kDa (ITGA4) and 81.09 kDa (ITGB7). Due to glycosylation, the protein migrates to 73-80 kDa, 110-120 kDa and 130-150 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Cynomolgus ITGA4&ITGB7, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Anti-ITGA4 Antibody, hFc Tag with the EC50 of 16.7ng/ml determined by ELISA.
Product Tag	C-His
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE
Endotoxin	Less than 0.1 EU per ug by the LAL method.

Shipping, Reconstitution, & Storage

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Validation Images

	Immobilized Cynomolgus ITGA4&ITGB7, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Anti-ITGA4 Antibody, hFc Tag with the EC50 of 16.7ng/ml determined by ELISA.
	Cynomolgus ITGA4&ITGB7 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	Loaded Anti-ITGA4 Antibody, hFc Tag on ProA-Biosensor can bind Cynomolgus ITGA4&ITGB7, His Tag with an affinity constant of 17.80 nM as determined in BLI assay (Gator® Prime).