Name: Cynomolgus Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein (ITG-CM147)
Brand: KactusBio
SKU: ITG-CM147-100UG
Price: 462.0 USD
Availability: InStock

Cynomolgus Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein (ITG-CM147)

Immobilized Cynomolgus ITGA4&ITGB7, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Anti-ITGA4 Antibody, hFc Tag with the EC50 of 4.2ng/ml determined by ELISA.

Cynomolgus ITGA4&ITGB7 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

Loaded Anti-ITGA4 Antibody, hFc Tag on ProA-Biosensor can bind Cynomolgus ITGA4&ITGB7, His Tag with an affinity constant of 17.80 nM as determined in BLI assay (Gator® Prime).

Express System: HEK293
Product Tag: C-His
Purity: > 95% as determined by Bis-Tris PAGE
Activity: Immobilized Cynomolgus ITGA4&ITGB7, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Anti-ITGA4 Antibody, hFc Tag with the EC50 of 4.2ng/ml determined by ELISA. See testing image for detail.
Amino Acid Range: Tyr34-Thr977(ITGA4) acidic tail & Glu20-His723(ITGB7) basic tail

Catalog #ITG-CM147

Size

100UG

500UG

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Cynomolgus Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein (ITG-CM147) Summary

Product Description	Recombinant Cynomolgus Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein is expressed from HEK293 with His tag at the C-terminus.It contains Tyr34-Thr977 (ITGA4) acidic tail and Glu20-His723 (ITGB7) basic tail.
Product Background	Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1.
Product Category	Recombinant Protein / Antibody discovery / Antibody discovery \| Others

Cynomolgus Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein (ITG-CM147) Specifications/Details

Protein	Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer
Synonyms	Integrin alpha 4 beta 7; beta7; alpha 4; LPAM; ITGA4&ITGB7;Integrin alpha 4 β 7; β7
Accession	XP_005573683.3(ITGA4)&XP_005571028.3(ITGB7)
Species	Cynomolgus
Biotinylated	no
Amino Acid Range	Tyr34-Thr977(ITGA4) acidic tail & Glu20-His723(ITGB7) basic tail
Molecular Weight	The protein has a predicted MW of 110.87 kDa (ITGA4) and 81.09 kDa (ITGB7). Due to glycosylation, the protein migrates to 73-80 kDa, 110-120 kDa and 130-150 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Cynomolgus ITGA4&ITGB7, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Anti-ITGA4 Antibody, hFc Tag with the EC50 of 4.2ng/ml determined by ELISA. See testing image for detail.
Product Tag	C-His
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE
Endotoxin	Less than 0.1 EU per ug by the LAL method.

Form	Liquid
Shipping	Shipped with dry ice.
Formulation	Supplied as 0.22 um filtered solution in PBS (pH 7.4).
Stability And Storage	Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Immobilized Cynomolgus ITGA4&ITGB7, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Anti-ITGA4 Antibody, hFc Tag with the EC50 of 4.2ng/ml determined by ELISA.
	Cynomolgus ITGA4&ITGB7 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	Loaded Anti-ITGA4 Antibody, hFc Tag on ProA-Biosensor can bind Cynomolgus ITGA4&ITGB7, His Tag with an affinity constant of 17.80 nM as determined in BLI assay (Gator® Prime).