Cynomolgus Integrin alpha V beta 3 (ITGAV&ITGB3) Heterodimer Protein (ITG-CM1V3)
Cynomolgus Integrin alpha V beta 3 (ITGAV&ITGB3) Heterodimer Protein (ITG-CM1V3)
  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Activity: Immobilized Cynomolgus ITGAV&ITGB3, His Tag at 1ug/ml (100ul/Well) on the plate. Dose response curve for Anti-alpha V beta 3 Antibody, hFc Tag with the EC50 of 8.0ng/ml determined by ELISA. See testing image for detail.
  • Amino Acid Range: Phe31-Pro993(ITGAV) acidic tail & Gly27-Asp718(ITGB3) basic tail
Catalog #ITG-CM1V3
Regular price $412.50
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Product Description

Recombinant Cynomolgus Integrin alpha V beta 3 (ITGAV&ITGB3) Heterodimer Protein is expressed from HEK293 with His tag at the C-Terminus of ITGAV.It contains Phe31-Pro993(ITGAV) acidic tail and Gly27-Asp718(ITGB3) basic tail.

Product Background

ITGAV&ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGAV&ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling. ITGAV&ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling. ITGAV&ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling. ITGAV&ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling.

Product Category

Recombinant Protein / Antibody discovery / Antibody discovery | Others

Protein

Integrin alpha V beta 3 (ITGAV&ITGB3) Heterodimer

Synonyms

αVβ3; Integrin alpha V beta 3; beta3; alphaV; ITGAV&ITGB3;Integrin alpha V β 3; β3

Accession

Species

Cynomolgus

Biotinylated

no

Amino Acid Range

Phe31-Pro993(ITGAV) acidic tail & Gly27-Asp718(ITGB3) basic tail

Molecular Weight

The protein has a predicted MW of 112.31 kDa (ITGAV) & 81.27 kDa (ITGB3). Due to glycosylation, the protein migrates 95-140 to kDa based on Bis-Tris PAGE result.

Activity

Immobilized Cynomolgus ITGAV&ITGB3, His Tag at 1ug/ml (100ul/Well) on the plate. Dose response curve for Anti-alpha V beta 3 Antibody, hFc Tag with the EC50 of 8.0ng/ml determined by ELISA. See testing image for detail.

Product Tag

C-His

Expression System

HEK293

Purity

> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC

Endotoxin

Less than 1 EU per ug by the LAL method.
Form
Lyophilized
Shipping
Shipped at ambient temperature.
Formulation
Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage
-20 to -80°C for 12 months as supplied from date of receipt.;-80°C for 3 months after reconstitution.;Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Immobilized Cynomolgus ITGAV&ITGB3, His Tag at 1ug/ml (100ul/Well) on the plate. Dose response curve for Anti-alpha V beta 3 Antibody, hFc Tag with the EC50 of 8.0ng/ml determined by ELISA. Immobilized Cynomolgus ITGAV&ITGB3, His Tag at 1ug/ml (100ul/Well) on the plate. Dose response curve for Anti-alpha V beta 3 Antibody, hFc Tag with the EC50 of 8.0ng/ml determined by ELISA.
Cynomolgus ITGAV&ITGB3 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. Cynomolgus ITGAV&ITGB3 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Cynomolgus ITGAV&ITGB3 is greater than 95% as determined by SEC-HPLC. The purity of Cynomolgus ITGAV&ITGB3 is greater than 95% as determined by SEC-HPLC.

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