Cynomolgus Integrin alpha V beta 3 (ITGAV&ITGB3) Heterodimer Protein (ITG-CM1V3)
Catalog: ITG-CM1V3
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| Product Description | Recombinant Cynomolgus Integrin alpha V beta 3 (ITGAV&ITGB3) Heterodimer Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Phe31-Pro993(ITGAV) acidic tail & Gly27-Asp718(ITGB3) basic tail. |
Product Background |
ITGAV&ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGAV&ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling. ITGAV&ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling. ITGAV&ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling. ITGAV&ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling. |
Product Category |
Recombinant Protein |
Target |
Integrin alpha V beta 3 (ITGAV&ITGB3) Heterodimer |
Gene/Protein ID |
A0A2K5WCD3(ITGAV)&A0A2K5WYN9(ITGB3) |
Species |
Cynomolgus |
Exact Sequence |
Phe31-Pro993(ITGAV)acidic tail & Gly27-Asp718(ITGB3)basic tail |
| Molecular Weight | The protein has a predicted MW of 112.31 kDa (ITGAV) & 81.27 kDa (ITGB3). Due to glycosylation, the protein migrates 95-140 to kDa based on Tris-Bis PAGE result. |
Activity |
Immobilized Cynomolgus ITGAV&ITGB3, His Tag at 0.5ug/ml (100ul/Well) on the plate. Dose response curve for Anti-alpha V beta 3 Antibody, hFc Tag with the EC50 of 10.1ng/ml determined by ELISA. See testing image for detail. |
Product Tag |
C-His |
Express System |
HEK293 |
| Purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
| Endotoxin | Less than 1EU per ug by the LAL method. |
| Form | Lyophilized |
| Shipping | Shipped at ambient temperature. |
| Formulation | Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
| Stability And Storage | Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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Immobilized Cynomolgus ITGAV&ITGB3, His Tag at 0.5ug/ml (100ul/Well) on the plate. Dose response curve for Anti-alpha V beta 3 Antibody, hFc Tag with the EC50 of 10.1ng/ml determined by ELISA. |
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The purity of Cynomolgus ITGAV&ITGB3 is greater than 95% as determined by SEC-HPLC. |
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Cynomolgus ITGAV&ITGB3 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. |
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