Product Description |
Recombinant Cynomolgus Kremen-2 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Gly26-Ala364. |
Product Background |
Kremen2 (Krm2) plays an important role in embryonic development, bone formation, and tumorigenesis as a crucial regulator of classical Wnt/β-catenin signaling pathway. Compared to para-cancerous tissues, Krm2 was significantly up-regulated in gastric cancer tissues and was positively correlated with the pathological grade of gastric cancer patients. Krm2 can be a potent candidate for designing of targeted therapy. |
Product Category |
Recombinant Protein |
Target |
Kremen-2 |
Synonyms |
KRM2; KREMEN2; Kremen-2; Dickkopf receptor 2 |
Accession |
|
Species |
Cynomolgus |
Biotinylated |
no |
Amino Acid Range |
Gly26-Ala364 |
Molecular Weight |
The protein has a predicted MW of 37.04 kDa. Due to glycosylation, the protein migrates to 50-65 kDa based on Bis-Tris PAGE result. |
Activity |
Immobilized Cynomolgus Kremen-2, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-Kremen-2 Antibody, hFc Tag with the EC50 of 4.8ng/ml determined by ELISA. See testing image for detail. |
Product Tag |
C-His |
Express System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage |
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
|
|
Immobilized Cynomolgus Kremen-2, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-Kremen-2 Antibody, hFc Tag with the EC50 of 4.8ng/ml determined by ELISA. |
|
|
Cynomolgus Kremen-2 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
|
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The purity of Cynomolgus Kremen-2 is greater than 95% as determined by SEC-HPLC. |
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