Name: Cynomolgus LGR-5 Protein (LGR-CM205)
Brand: KactusBio
SKU: LGR-CM205-100UG
Price: 345.0 USD
Availability: InStock

Express System: HEK293
Product Tag: C-hFc (IgG1)
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: Immobilized Cynomolgus LGR-5, hFc Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-LGR-5 Antibody, hFc Avi Tag with the EC50 of 5.9ng/ml determined by ELISA.
Amino Acid Range: Ser22-Gly557

Catalog #LGR-CM205

Size

100UG

500UG

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Cynomolgus LGR-5 Protein (LGR-CM205) Summary

Product Description	Recombinant Cynomolgus LGR-5 Protein is expressed from HEK293 with hFc (IgG1) tag at the C-terminus.It contains Ser22-Gly557.
Product Background	G protein-coupled receptor 5 (LGR5), known as a stem cell marker for colon cancer and gastric cancer, can serve as a novel GSC marker involved in EMT and a therapeutic target in glioma.LGR5 is a new functional GSC marker and prognostic indicator that can promote EMT by activating the Wnt/β-catenin pathway and would thus be a novel therapeutic target for glioma.
Product Category	Recombinant Protein / Antibody discovery / Antibody discovery/Others

Cynomolgus LGR-5 Protein (LGR-CM205) Specifications/Details

Protein	LGR-5
Synonyms	LGR5; GPR49; GPR67; HG38; G-protein coupled receptor 49; G-protein coupled receptor 67; G-protein coupled receptor HG38
Accession	G7PI19
Species	Cynomolgus
Biotinylated	no
Amino Acid Range	Ser22-Gly557
Molecular Weight	The protein has a predicted MW of 84.60 kDa. Due to glycosylation, the protein migrates to 90-110 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Cynomolgus LGR-5, hFc Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-LGR-5 Antibody, hFc Avi Tag with the EC50 of 5.9ng/ml determined by ELISA.
Product Tag	C-hFc (IgG1)
Fluorophore	Unconjugated
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 0.1 EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22 um filtered solution in PBS, 50mM L-Arginine (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Immobilized Cynomolgus LGR-5, hFc Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-LGR-5 Antibody, hFc Avi Tag with the EC50 of 5.9ng/ml determined by ELISA.
	Cynomolgus LGR-5 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Cynomolgus LGR-5 is greater than 95% as determined by SEC-HPLC.

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