Name: Cynomolgus LILRA4/CD85g Protein (LIL-CM1A4)
Brand: KactusBio
SKU: LIL-CM1A4-100UG
Price: 270.0 USD
Availability: InStock

Cynomolgus LILRA4/CD85g Protein (LIL-CM1A4)

Cynomolgus LILRA4 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

The purity of Cynomolgus LILRA4 is greater than 95% as determined by SEC-HPLC.

Express System: HEK293
Product Tag: C-His
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Amino Acid Range: Glu24-Asn446

Catalog #LIL-CM1A4

Size

100UG

500UG

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Product Description	Recombinant Cynomolgus LILRA4/CD85g Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Glu24-Asn446.
Product Background	LILRA4, also known as ILT7 and CD85g, is an approximately 60-70 kDa variably glycosylated transmembrane protein that regulates immune cell activation. Mature human LILRA4 consists of a 423 amino acid (aa) extracellular domain (ECD) with four immunoglobulin-like domains, a 21 aa transmembrane segment, and a 32 aa cytoplasmic domain.LILRA4 function coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G (PubMed:16735691, PubMed:19564354). Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as negative regulator of TLR7 and TLR9 signaling cascades.
Product Category	Recombinant Protein / Antibody discovery / Immune checkpoint proteins

Protein	LILRA4/CD85g
Synonyms	CD85g; ILT7; ILT-7; ILT7MGC129598; LILRA4; MGC129597
Accession	XP_005590346.1
Species	Cynomolgus
Biotinylated	no
Amino Acid Range	Glu24-Asn446
Molecular Weight	The protein has a predicted MW of 47.7 kDa. Due to glycosylation, the protein migrates to 58-68 kDa based on Bis-Tris PAGE result.
Product Tag	C-His
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Cynomolgus LILRA4 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Cynomolgus LILRA4 is greater than 95% as determined by SEC-HPLC.