Cynomolgus LILRB2/CD85d/ILT4 Protein (LIL-CM2B2)
Catalog: LIL-CM2B2
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| Product Description | Recombinant Cynomolgus LILRB2/CD85d/ILT4 Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Gly24-Arg457. |
Product Background |
The immunoglobulin-like transcript (ILT) comprise a family of activating and inhibitory type immunoreceptors whose genes are located in the same locus that encodes killer cell Ig-like receptors (KIR). ILT4, also known as LIR-2 and LILRB2, is a type I transmembrane protein expressed primarily on monocytes and dendritic cells (DC). LILRB2 is a receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles. |
Product Category |
Recombinant Protein |
Target |
LILRB2/CD85d/ILT4 |
| Synonyms | CD85d; ILT4; ILT-4; ILT4CD85d; LILRB2; LIR2; MIR10 |
Gene/Protein ID |
XP_015297203.1 |
Species |
Cynomolgus |
Exact Sequence |
Gly24-Arg457 |
| Molecular Weight | The protein has a predicted MW of 71.68 kDa. Due to glycosylation, the protein migrates to 80-90 kDa based on Tris-Bis PAGE result. |
Activity |
The affinity constant of 42.50 nM as determined in SPR assay (Biacore T200). See testing image for detail. |
Product Tag |
C-hFc |
Express System |
HEK293 |
| Purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
| Endotoxin | Less than 1EU per ug by the LAL method. |
| Form | Lyophilized |
| Shipping | Shipped at ambient temperature. |
| Formulation | Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
| Stability And Storage | Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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Cynomolgus LILRB2, hFc Tag captured on CM5 Chip via Protein A can bind Cynomolgus HLA-G Complex Tetramer, His Tag with an affinity constant of 42.50 nM as determined in SPR assay (Biacore T200). |
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The purity of Cynomolgus LILRB2 is greater than 95% as determined by SEC-HPLC. |
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Cynomolgus LILRB2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. |
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