Cynomolgus LILRB2/CD85d/ILT4 Protein (LIL-CM2B2)

  • Express System: HEK293
  • Product Tag: C-hFc
  • Purity: > 95% as determined by Tris-Bis PAGE
  • Activity: The affinity constant of 42.50 nM as determined in SPR assay (Biacore T200). See testing image for detail.
  • Exact Sequence: Gly24-Arg457

Catalog: LIL-CM2B2

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Product Description Recombinant Cynomolgus LILRB2/CD85d/ILT4 Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Gly24-Arg457.

Product Background

 The immunoglobulin-like transcript (ILT) comprise a family of activating and inhibitory type immunoreceptors whose genes are located in the same locus that encodes killer cell Ig-like receptors (KIR). ILT4, also known as LIR-2 and LILRB2, is a type I transmembrane protein expressed primarily on monocytes and dendritic cells (DC). LILRB2 is a receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles.

Product Category

 Recombinant Protein

Target

 LILRB2/CD85d/ILT4
Synonyms CD85d; ILT4; ILT-4; ILT4CD85d; LILRB2; LIR2; MIR10

Gene/Protein ID

 XP_015297203.1

Species

 Cynomolgus

Exact Sequence

 Gly24-Arg457
Molecular Weight The protein has a predicted MW of 71.68 kDa. Due to glycosylation, the protein migrates to 80-90 kDa based on Tris-Bis PAGE result.

Activity

 The affinity constant of 42.50 nM as determined in SPR assay (Biacore T200). See testing image for detail.

Product Tag

 C-hFc

Express System

 HEK293
Purity > 95% as determined by Tris-Bis PAGE
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Cynomolgus LILRB2, hFc Tag captured on CM5 Chip via Protein A can bind Cynomolgus HLA-G Complex Tetramer, His Tag with an affinity constant of 42.50 nM as determined in SPR assay (Biacore T200).
Cynomolgus LILRB2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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