Cynomolgus LY6G6D-Protein (LYD-CM16D)

Express System: HEK293
Product Tag: N-His
Purity: > 95% as determined by Tris-Bis PAGE
Activity: Immobilized Cynomolgus LY6G6D, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-LY6G6D Antibody, hFc Tag with the EC50 of 4.0ng/ml determined by ELISA. See testing image for detail.
Exact Sequence: Asn20-Ser104

Catalog: LYD-CM16D

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Product Description	Recombinant Cynomolgus LY6G6D-Protein is expressed from HEK293 with His tag at the N-terminus.It contains Asn20-Ser104.
Product Background	LY6G6D is a selectively expressed colorectal cancer antigen that can be used for targeting a therapeutic T-cell response by a T-cell engager.LY6G6D was identified as a selectively expressed CRC antigen that can be utilized to potently re-direct and activate cytotoxic T-cells to lyse LY6G6D expressing CRC using a TcE. This effect can be spread to target negative neighboring tumor cells, potentially leading to improved therapeutic efficacy.
Product Category	Recombinant Protein

Target	LY6G6D
Gene/Protein ID	XP_045246087.1
Species	Cynomolgus
Exact Sequence	Asn20-Ser104
Molecular Weight	The protein has a predicted MW of 10.22 kDa. Due to glycosylation, the protein migrates to 14-24 kDa based on Tris-Bis PAGE result.
Activity	Immobilized Cynomolgus LY6G6D, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-LY6G6D Antibody, hFc Tag with the EC50 of 4.0ng/ml determined by ELISA. See testing image for detail.
Product Tag	N-His
Express System	HEK293
Purity	> 95% as determined by Tris-Bis PAGE
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

	Immobilized Cynomolgus LY6G6D, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-LY6G6D Antibody, hFc Tag with the EC50 of 4.0ng/ml determined by ELISA.
	Cynomolgus LY6G6D on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.