Cynomolgus LY6G6D-Protein (LYD-CM16D) Summary
Product Description |
Recombinant Cynomolgus LY6G6D-Protein is expressed from HEK293 with His tag at the N-terminus.It contains Asn20-Ser104. |
Product Background |
LY6G6D is a selectively expressed colorectal cancer antigen that can be used for targeting a therapeutic T-cell response by a T-cell engager.LY6G6D was identified as a selectively expressed CRC antigen that can be utilized to potently re-direct and activate cytotoxic T-cells to lyse LY6G6D expressing CRC using a TcE. This effect can be spread to target negative neighboring tumor cells, potentially leading to improved therapeutic efficacy. |
Product Category |
Recombinant Protein / Antibody discovery / Antibody discovery | Others |
Cynomolgus LY6G6D-Protein (LYD-CM16D) Specifications/Details
Protein |
LY6G6D |
Synonyms |
Protein Ly6-D; C6orf23; G6D; MEGT1; NG25 |
Accession |
|
Species |
Cynomolgus |
Biotinylated |
no |
Amino Acid Range |
Asn20-Ser104 |
Molecular Weight |
The protein has a predicted MW of 10.22 kDa. Due to glycosylation, the protein migrates to 14-24 kDa based on Bis-Tris PAGE result. |
Activity |
Immobilized Cynomolgus LY6G6D, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-LY6G6D Antibody, hFc Tag with the EC50 of 3.3ng/ml determined by ELISA. See testing image for detail. |
Product Tag |
N-His |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE |
Endotoxin |
Less than 1 EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
Stability And Storage |
-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
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Immobilized Cynomolgus LY6G6D, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-LY6G6D Antibody, hFc Tag with the EC50 of 3.3ng/ml determined by ELISA. |
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Cynomolgus LY6G6D on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
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