Product Description |
Recombinant Cynomolgus LY6G6D Protein is expressed from HEK293 with hFc tag at the N-terminus.It contains Asn20-Ser104. |
Product Background |
LY6G6D is a selectively expressed colorectal cancer antigen that can be used for targeting a therapeutic T-cell response by a T-cell engager.LY6G6D was identified as a selectively expressed CRC antigen that can be utilized to potently re-direct and activate cytotoxic T-cells to lyse LY6G6D expressing CRC using a TcE. This effect can be spread to target negative neighboring tumor cells, potentially leading to improved therapeutic efficacy. |
Product Category |
Recombinant Protein |
Target |
LY6G6D |
Accession |
|
Species |
Cynomolgus |
Biotinylated |
no |
Amino Acid Range |
Asn20-Ser104 |
Molecular Weight |
The protein has a predicted MW of 34.65 kDa. Due to glycosylation, the protein migrates to 40-50 kDa based on Bis-Tris PAGE result. |
Activity |
Immobilized Cynomolgus LY6G6D, hFc Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-LY6G6D Antibody, hFc Tag with the EC50 of 12.2ng/ml determined by ELISA. See testing image for detail. |
Product Tag |
N-hFc |
Express System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Liquid |
Shipping |
Shipped with dry ice. |
Formulation |
Supplied as 0.22 um filtered solution in PBS (pH 7.4). |
Stability And Storage |
Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
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|
Immobilized Cynomolgus LY6G6D, hFc Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-LY6G6D Antibody, hFc Tag with the EC50 of 12.2ng/ml determined by ELISA. |
|
|
Cynomolgus LY6G6D on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
|
|
The purity of Cynomolgus LY6G6D is greater than 95% as determined by SEC-HPLC. |
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