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Cynomolgus Oncostatin M/OSM Protein (OSM-CM102) Summary
Product Description |
Recombinant Cynomolgus Oncostatin M/OSM Protein is expressed from HEK293 with His tag at the C-terminus.It contains Ala27-Arg221. |
Product Background |
OSM is a pleiotropic cytokine that initiates its biological activities by binding to specific cell surface receptors. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIFR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration. |
Product Category |
Recombinant Protein / Antibody discovery / Antibody discovery | Others |
Cynomolgus Oncostatin M/OSM Protein (OSM-CM102) Specifications/Details
Protein |
Oncostatin M/OSM |
Synonyms |
Oncostatin M; OSM |
Accession |
|
Species |
Cynomolgus |
Biotinylated |
no |
Amino Acid Range |
Ala27-Arg221 |
Molecular Weight |
The protein has a predicted MW of 23.31 kDa. Due to glycosylation, the protein migrates to 27-50 kDa based on Bis-Tris PAGE result. |
Activity |
The affinity constant of 1.31 uM as determined in SPR assay (Biacore T200). |
Product Tag |
C-His |
Fluorophore |
Unconjugated |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1 EU per ug by the LAL method. |
Shipping, Reconstitution, & Storage
Form |
Liquid |
Shipping |
Shipped with dry ice. |
Formulation |
Supplied as 0.22 um filtered solution in PBS (pH 7.4). |
Stability And Storage |
Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Validation Images
|
|
Human LIF R, hFc Tag captured on CM5 Chip via Protein A can bind Cynomolgus OSM, His Tag with an affinity constant of 1.31 uM as determined in SPR assay (Biacore T200). |
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Cynomolgus Oncostatin M on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
|
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The purity of Cynomolgus Oncostatin M is greater than 95% as determined by SEC-HPLC. |
Other Available Proteins:
Finding available proteins...
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