Name: Cynomolgus PLAU/uPA Protein (active form) (PLA-CM101)
Brand: KactusBio
SKU: PLA-CM101-100UG
Price: 346.5 USD
Availability: InStock

Cynomolgus PLAU/uPA Protein (active form) (PLA-CM101)

Cynomolgus uPAR, His Tag immobilized on CM5 Chip can bind Cynomolgus PLAU, His Tag with an affinity constant of 0.033 nM as determined in SPR assay (Biacore T200).

Immobilized Cynomolgus PLAU, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Human uPAR, hFc Tag with the EC50 of 21.4ng/ml determined by ELISA (QC Test).

Cynomolgus PLAU (active form) on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

The purity of Cynomolgus PLAU (active form) is greater than 95% as determined by SEC-HPLC.

Express System: HEK293
Product Tag: C-His
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: Immobilized Cynomolgus PLAU, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Human uPAR, hFc Tag with the EC50 of 21.4ng/ml determined by ELISA (QC Test). The affinity constant of 0.033 nM as determined in SPR assay (Biacore T200). See testing image for detail.
Amino Acid Range: Ser21-Leu430

Catalog #PLA-CM101

Size

100UG

500UG

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Product Description	Recombinant Cynomolgus PLAU/uPA Protein (active form) is expressed from HEK293 with His tag at the C-Terminus.It contains Ser21-Leu430, which consists of two chains: Long chain A and chain B. The long chain A is further cleaved to yield a short chain A and N-Terminus fragment.
Product Background	Plasminogen activator, urokinase (uPA) is a secreted serine protease whose Dysregulation is often accompanied by various cancers. PLAU inhibition could suppress tumor growth. Collectively, PLAU is necessary for tumor progression and can be a diagnostic and prognostic biomarker in HNSCC.
Product Category	Recombinant Protein / Antibody discovery / Antibody discovery \| Others

Protein	PLAU/uPA
Synonyms	PLAU; Urokinase; ATF; UPA; URK; u-PA; BDPLT5; QPD
Accession	A0A2K5WND1
Species	Cynomolgus
Biotinylated	no
Amino Acid Range	Ser21-Leu430
Molecular Weight	The protein has a predicted MW of 47.23 kDa. Due to protein lysis and glycosylation, the protein migrates to 23-25 kDa, 35-40 kDa and 50-60 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Cynomolgus PLAU, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Human uPAR, hFc Tag with the EC50 of 21.4ng/ml determined by ELISA (QC Test). The affinity constant of 0.033 nM as determined in SPR assay (Biacore T200). See testing image for detail.
Product Tag	C-His
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1 EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Cynomolgus uPAR, His Tag immobilized on CM5 Chip can bind Cynomolgus PLAU, His Tag with an affinity constant of 0.033 nM as determined in SPR assay (Biacore T200).
	Immobilized Cynomolgus PLAU, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Human uPAR, hFc Tag with the EC50 of 21.4ng/ml determined by ELISA (QC Test).
	Cynomolgus PLAU (active form) on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Cynomolgus PLAU (active form) is greater than 95% as determined by SEC-HPLC.

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