Name: Cynomolgus PVRIG Protein (PVR-CM101)
Brand: KactusBio
SKU: PVR-CM101-100UG
Price: 363.0 USD
Availability: InStock

Express System: HEK293
Product Tag: C-His
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: Immobilized Cynomolgus PVRIG, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-PVRIG Antibody, hFc Tag with the EC50 of 2.0ng/ml determined by ELISA (QC Test). See testing image for detail.
Amino Acid Range: Thr41-Asp171

Catalog #PVR-CM101

Size

100UG

500UG

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Product Description	Recombinant Cynomolgus PVRIG Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Thr41-Asp171.
Product Background	PVRIG (poliovirus receptor related immunoglobulin domain-containing protein), also known as CD112 receptor (CD112R), is an approximately 34 kDa single transmembrane protein in the poliovirus receptor-like protein (PVR) family.PVRIG is a cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T-cell proliferation. Competes with CD226 for NECTIN2-binding.
Product Category	Recombinant Protein / Antibody discovery / Immune checkpoint proteins

Protein	PVRIG
Synonyms	C7orf15; CD112R; MGC104322; MGC138297; MGC2463; PVRIG; ALS2CR18; ALS2CR9; LPD; PREL-2; PREL2; RalGDS/AF-6; RMO1
Accession	A0A2K5WVV8
Species	Cynomolgus
Biotinylated	no
Amino Acid Range	Thr41-Asp171
Molecular Weight	The protein has a predicted MW of 14.78 kDa. Due to glycosylation, the protein migrates to 25-30 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Cynomolgus PVRIG, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-PVRIG Antibody, hFc Tag with the EC50 of 2.0ng/ml determined by ELISA (QC Test). See testing image for detail.
Product Tag	C-His
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1 EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Immobilized Cynomolgus PVRIG, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-PVRIG Antibody, hFc Tag with the EC50 of 2.0ng/ml determined by ELISA (QC Test).
	Cynomolgus PVRIG on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Cynomolgus PVRIG is greater than 95% as determined by SEC-HPLC.