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Cynomolgus/Rhesus macaque TNFSF15 Protein (FSF-CM215) Summary
Product Description |
Recombinant Cynomolgus/Rhesus macaque TNFSF15 Protein is expressed from HEK293 with monomeric Fc tag at the N-terminus.It contains Leu72-Leu251. |
Product Background |
TNF superfamily member 15 (TNFSF15), a cytokine largely produced by vascular endothelial cells and a specific inhibitor of the proliferation of these same cells, can inhibit VEGF-induced vascular permeability in vitro and in vivo, and that death receptor 3 (DR3), a cell surface receptor of TNFSF15, mediates TNFSF15-induced dephosphorylation of VEGFR2. |
Product Category |
Recombinant Protein / Antibody discovery / Antibody discovery/Others |
Cynomolgus/Rhesus macaque TNFSF15 Protein (FSF-CM215) Specifications/Details
Protein |
TNFSF15 |
Synonyms |
TL1A; VEGI-251; TNFSF15; TL1; VEGI; VEGI192A; TNF superfamily member 15 |
Accession |
|
Species |
Cynomolgus/Rhesus macaque |
Biotinylated |
no |
Amino Acid Range |
Leu72-Leu251 |
Molecular Weight |
The protein has a predicted MW of 44.82 kDa. Due to glycosylation, the protein migrates to 50-60 kDa based on Bis-Tris PAGE result. |
Activity |
Immobilized Mouse DR3, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Cynomolgus/Rhesus macaque TNFSF15, hFc Tag with the EC50 of 27.1ng/ml determined by ELISA (QC Test). |
Product Tag |
N-monomeric Fc |
Fluorophore |
Unconjugated |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 90% as determined by HPLC |
Endotoxin |
Less than 1 EU per ug by the LAL method. |
Shipping, Reconstitution, & Storage
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22 um filtered solution in PBS, 8% trehalose (pH 7.4). |
Reconstitution |
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
Stability And Storage |
-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Validation Images
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Immobilized Mouse DR3, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Cynomolgus/Rhesus macaque TNFSF15, hFc Tag with the EC50 of 27.1ng/ml determined by ELISA (QC Test). |
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Immobilized Cynomolgus/Rhesus macaque TNFSF15, hFc Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-TNFSF15 Antibody, hFc Tag with the EC50 of 14.6ng/ml determined by ELISA. |
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Cynomolgus/Rhesus macaque TNFSF15 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
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The purity of Cynomolgus/Rhesus macaque TNFSF15 is greater than 90% as determined by SEC-HPLC. |
Other Available Proteins:
Finding available proteins...
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