Cynomolgus Siglec-10 Protein (SIG-CM110)
Catalog: SIG-CM110
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Product Description | Recombinant Cynomolgus Siglec-10 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Thr17-Asn552. |
Product Background |
Siglec-10 is a ligand for CD52, the target of the therapeutic monoclonal antibody Alemtuzumab. It is also reported to bind to Vascular adhesion protein 1 (VAP-1) and to the co-stimulatory molecule CD24 also known as HSA (Heat-stable antigen).Siglecs (sialic acid binding Ig-like lectins) are I-type lectins that belong to the immunoglobulin superfamily. They are characterized by an N-terminal Ig-like V-type domain which mediates sialic acid binding, followed by a varying number of Ig-like C2-type domains. Siglecs 5-11 constitute the CD33/Siglec-3 related group, and are differentially expressed in the hematopoietic system. |
Product Category |
Recombinant Protein |
Target |
Siglec-10 |
Accession | |
Species |
Cynomolgus |
Amino Acid Range |
Thr17-Asn552 |
Molecular Weight | The protein has a predicted MW of 59.90 kDa. Due to glycosylation, the protein migrates to 70-80 kDa based on Tris-Bis PAGE result. |
Activity |
Immobilized Cynomolgus Siglec-10, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Anti-Siglec-10 Antibody, hFc Tag with the EC50 of 17.7ng/ml determined by ELISA. See testing image for detail. |
Product Tag |
C-His |
Express System |
HEK293 |
Purity | > 95% as determined by Tris-Bis PAGE;> 90% as determined by HPLC |
Endotoxin | Less than 1EU per ug by the LAL method. |
Form | Liquid |
Shipping | Shipped with dry ice. |
Formulation | Supplied as 0.22um filtered solution in 25mM MES, 150mM NaCl, 0.5M Arginine (pH 5.0). |
Stability And Storage | Valid for 12 months from date of receipt when stored at -80°C.;Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
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