Non-biotinylated Cynomolgus Siglec-15/CD33L3 Protein (SIG-CM415)

Express System: HEK293
Product Tag: C-His-Avi
Purity: > 95% as determined by Bis-Tris PAGE
Activity: Immobilized Cynomolgus Siglec-15, His Tag at 1ug/ml (100ul/Well) on the plate. Dose response curve for Anti-Siglec-15 Antibody, hFc Tag with the EC50 of 3.8ng/ml determined by ELISA (QC Test).
Amino Acid Range: Met60-Thr322

Catalog #SIG-CM415

Price

$346⁵⁰

Size

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Non-biotinylated Cynomolgus Siglec-15/CD33L3 Protein (SIG-CM415) Summary

Product Description

Recombinant Cynomolgus Siglec-15/CD33L3 Protein is expressed from HEK293 with His and Avi tag at the C-Terminus.It contains Met60-Thr322.

Product Background

Siglec-15 is a transmembrane glycoprotein in the Siglec family of sialic acid-binding immune regulatory molecules. Mature human Siglec-15 consists of a 244 amino acid extracellular domain (ECD) with two Ig-like domains, a 21 aa transmembrane segment, and a 44 aa cytoplasmic domain. Siglec-15 is a potential therapeutic target for osteoporosis and plays a conserved regulatory role in the immune system of vertebrates.

Non-biotinylated Cynomolgus Siglec-15/CD33L3 Protein (SIG-CM415) Specifications/Details

Protein	Siglec-15/CD33L3
Synonyms	CD33 molecule-like 3; CD33L3; HsT1361; Siglec15; CD33 antigen-like 3; SIGLEC-15
Accession	XP_005586866.2
Species	Cynomolgus
Biotinylated	no
Amino Acid Range	Met60-Thr322
Molecular Weight	The protein has a predicted MW of 29.2 kDa. Due to glycosylation, the protein migratesto 33-43 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Cynomolgus Siglec-15, His Tag at 1ug/ml (100ul/Well) on the plate. Dose response curve for Anti-Siglec-15 Antibody, hFc Tag with the EC50 of 3.8ng/ml determined by ELISA (QC Test).
Product Tag	C-His-Avi
Fluorophore	Unconjugated
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE
Endotoxin	Less than 1 EU per ug by the LAL method.

Shipping, Reconstitution, & Storage

Form	Liquid
Shipping	Shipped with dry ice.
Formulation	Supplied as 0.22um filtered solution in 20mM PB, 500mM NaCl, 0.1M L-arginine (pH 6.0).
Stability And Storage	Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Validation Images

	Immobilized Cynomolgus Siglec-15, His Tag at 1ug/ml (100ul/Well) on the plate. Dose response curve for Anti-Siglec-15 Antibody, hFc Tag with the EC50 of 3.8ng/ml determined by ELISA (QC Test).
	Cynomolgus Siglec-15 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.