Cynomolgus Siglec-15/CD33L3 Protein (SIG-CM415)

  • Express System: HEK293
  • Product Tag: C-His-Avi
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Activity: Immobilized Cynomolgus Siglec-15, His Tag at 0.5ug/ml (100ul/Well) on the plate. Dose response curve for Anti-Siglec-15 Antibody, hFc Tag with the EC50 of 5.6ng/ml determined by ELISA. See testing image for detail.
  • Exact Sequence: Met60-Thr322

Catalog: SIG-CM415

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Product Description Recombinant Cynomolgus Siglec-15/CD33L3 Protein is expressed from HEK293 with His and Avi tag at the C-Terminus.It contains Met60-Thr322.

Product Background

 Siglec-15 is a transmembrane glycoprotein in the Siglec family of sialic acid-binding immune regulatory molecules. Mature human Siglec-15 consists of a 244 amino acid extracellular domain (ECD) with two Ig-like domains, a 21 aa transmembrane segment, and a 44 aa cytoplasmic domain. Siglec-15 is a potential therapeutic target for osteoporosis and plays a conserved regulatory role in the immune system of vertebrates.

Product Category

 Recombinant Protein

Target

 Siglec-15/CD33L3
Synonyms CD33 molecule-like 3; CD33L3; HsT1361; Siglec15; CD33 antigen-like 3; SIGLEC-15

Gene/Protein ID

 XP_005586866.2

Species

 Cynomolgus

Exact Sequence

 Met60-Thr322
Molecular Weight The protein has a predicted MW of 29.2 kDa. Due to glycosylation, the protein migratesto 33-43 kDa based on Tris-Bis PAGE result.

Activity

 Immobilized Cynomolgus Siglec-15, His Tag at 0.5ug/ml (100ul/Well) on the plate. Dose response curve for Anti-Siglec-15 Antibody, hFc Tag with the EC50 of 5.6ng/ml determined by ELISA. See testing image for detail.

Product Tag

 C-His-Avi

Express System

 HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Liquid
Shipping Shipped with dry ice.
Formulation Supplied as 0.22um filtered solution in 20mM PB, 500mM NaCl, 0.1M L-arginine (pH 6.0).
Stability And Storage Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Immobilized Cynomolgus Siglec-15, His Tag at 0.5ug/ml (100ul/Well) on the plate. Dose response curve for Anti-Siglec-15 Antibody, hFc Tag with the EC50 of 5.6ng/ml determined by ELISA.
The purity of Cynomolgus Siglec-15 is greater than 95% as determined by SEC-HPLC.
Cynomolgus Siglec-15 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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