Cynomolgus SOST/Sclerostin Protein (SOT-CM101)
Catalog: SOT-CM101
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Product Description | Recombinant Cynomolgus SOST/Sclerostin Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Gln69-Tyr258. |
Product Background |
SOST, also known as sclerostin, is a member of the cerberus/DAN family, a group of secreted glycoproteins characterized by a cysteine-knot motif. SOST is negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation. |
Product Category |
Recombinant Protein |
Target |
SOST/Sclerostin |
Accession | |
Species |
Cynomolgus |
Amino Acid Range |
Gln69-Tyr258 |
Molecular Weight | The protein has a predicted MW of 22.58 kDa. Due to glycosylation, the protein migrates to 30-40 kDa based on Tris-Bis PAGE result. |
Activity |
Immobilized Cynomolgus SOST, His Tag at 0.2ug/ml (100ul/Well) on the plate. Dose response curve for Anti-SOST Antibody, hFc Tag with the EC50 of 10.0ng/ml determined by ELISA. See testing image for detail. |
Product Tag |
C-His |
Express System |
HEK293 |
Purity | > 95% as determined by Tris-Bis PAGE |
Endotoxin | Less than 1EU per ug by the LAL method. |
Form | Lyophilized |
Shipping | Shipped at ambient temperature. |
Formulation | Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage | Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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