Name: Cynomolgus TIM-3/HAVCR2 Protein (TIM-CM131)
Brand: KactusBio
SKU: TIM-CM131-100UG
Price: 315.0 USD
Availability: InStock

Cynomolgus TIM-3/HAVCR2 Protein (TIM-CM131)

Immobilized Cynomolgus TIM-3, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-TIM-3 Antibody, hFc Tag with the EC50 of 3.3ng/ml determined by ELISA (QC Test).

Cynomolgus TIM-3 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

Express System: HEK293
Product Tag: C-His
Purity: > 95% as determined by Bis-Tris PAGE
Activity: Immobilized Cynomolgus TIM-3, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-TIM-3 Antibody, hFc Tag with the EC50 of 3.3ng/ml determined by ELISA (QC Test). See testing image for detail.
Amino Acid Range: Ser22-Arg201

Catalog #TIM-CM131

Size

100UG

500UG

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Product Description	Recombinant Cynomolgus TIM-3/HAVCR2 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Ser22-Arg201.
Product Background	Hepatitis A virus cellular receptor 2 (HAVCR2), also known as T-cell immunoglobulin and mucin-domain containing-3 (TIM-3), is a protein that in humans is encoded by the HAVCR2 gene.TIM3 is an immune checkpoint and together with other inhibitory receptors including programmed cell death protein 1 (PD-1) and lymphocyte activation gene 3 protein (LAG3) mediate the CD8 T-cell exhaustion. TIM3 has also been shown as a CD4 Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice.
Product Category	Recombinant Protein / Antibody discovery / Immune checkpoint proteins

Protein	TIM-3/HAVCR2
Synonyms	CD366; TIM3; TIM-3; TIMD-3; TIM 3;-FLJ14428; HAVCR2; KIM3
Accession	EHH54703.1
Species	Cynomolgus
Biotinylated	no
Amino Acid Range	Ser22-Arg201
Molecular Weight	The protein has a predicted MW of 20.8 kDa. Due to glycosylation, the protein migrates to 45-55 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Cynomolgus TIM-3, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-TIM-3 Antibody, hFc Tag with the EC50 of 3.3ng/ml determined by ELISA (QC Test). See testing image for detail.
Product Tag	C-His
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Immobilized Cynomolgus TIM-3, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-TIM-3 Antibody, hFc Tag with the EC50 of 3.3ng/ml determined by ELISA (QC Test).
	Cynomolgus TIM-3 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.