Cynomolgus TLR3 Protein (TLR-CM103)
Cynomolgus TLR3 Protein (TLR-CM103)
  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Amino Acid Range: Ser31-Glu711
Catalog #TLR-CM103
Regular price $315.00
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Product Description
Recombinant Cynomolgus TLR3 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Ser31-Glu711.
Product Background
TLR3 is expressed in the central nervous system (CNS), where it is required to control HSV-1, which spreads from the epithelium to the CNS via cranial nerves. TLR3 is also expressed in epithelial and dendritic cells, which apparently use TLR3-independent pathways to prevent further dissemination of HSV-1 and to provide resistance to other pathogens in TLR3-deficient patients. Human TLR3 appears to be redundant in host defense to most microbes but is vital for natural immunity to HSV-1 in the CNS, which suggests that neurotropic viruses have contributed to the evolutionary maintenance of TLR3.
Product Category
Recombinant Protein
Target
TLR3
Accession
Species
Cynomolgus
Biotinylated
no
Amino Acid Range
Ser31-Glu711
Molecular Weight
The protein has a predicted MW of 78.04 kDa. Due to glycosylation, the protein migrates to 95-115 kDa based on Bis-Tris PAGE result.
Product Tag
C-His
Express System
HEK293
Purity
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin
Less than 1EU per ug by the LAL method.
Form
Lyophilized
Shipping
Shipped at ambient temperature.
Formulation
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Cynomolgus TLR3 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Cynomolgus TLR3 is greater than 95% as determined by SEC-HPLC.

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