Cynomolgus TLR3 Protein (TLR-CM103)

  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Exact Sequence: Ser31-Glu711

Catalog: TLR-CM103

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Product Description Recombinant Cynomolgus TLR3 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Ser31-Glu711.

Product Background

 TLR3 is expressed in the central nervous system (CNS), where it is required to control HSV-1, which spreads from the epithelium to the CNS via cranial nerves. TLR3 is also expressed in epithelial and dendritic cells, which apparently use TLR3-independent pathways to prevent further dissemination of HSV-1 and to provide resistance to other pathogens in TLR3-deficient patients. Human TLR3 appears to be redundant in host defense to most microbes but is vital for natural immunity to HSV-1 in the CNS, which suggests that neurotropic viruses have contributed to the evolutionary maintenance of TLR3.

Product Category

 Recombinant Protein

Target

 TLR3

Gene/Protein ID

 A0A2K5WT39

Species

 Cynomolgus

Exact Sequence

 Ser31-Glu711
Molecular Weight The protein has a predicted MW of 78.04 kDa. Due to glycosylation, the protein migrates to 95-115 kDa based on Tris-Bis PAGE result.

Product Tag

 C-His

Express System

 HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
The purity of Cynomolgus TLR3 is greater than 95% as determined by SEC-HPLC.
Cynomolgus TLR3 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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