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Cynomolgus ULBP-2 Protein, Ultra Low Endotoxin (ULB-CM102-UL) Summary
Product Description |
Recombinant Cynomolgus ULBP-2 Protein is expressed from HEK293 with His tag at the C-terminus.It contains Gly26-Ser216. |
Product Background |
ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway, mediating natural killer cell cytotoxicity. |
Product Category |
Recombinant Protein / Antibody discovery / Antibody discovery/Others |
Cynomolgus ULBP-2 Protein, Ultra Low Endotoxin (ULB-CM102-UL) Specifications/Details
Protein |
ULBP-2 |
Synonyms |
ALCAN-alpha; N2DL2; NKG2DL2; RAET1H; RAET1L; ULBP2; ULBP-2/5/6; NKG2D ligand 2 |
Accession |
|
Species |
Cynomolgus |
Biotinylated |
no |
Amino Acid Range |
Gly26-Ser216 |
Molecular Weight |
The protein has a predicted MW of 23.38 kDa. Due to glycosylation, the protein migrates to 25-30 kDa based on Bis-Tris PAGE result. |
Product Tag |
C-His |
Fluorophore |
Unconjugated |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 0.01 EU per ug by the LAL method. |
Shipping, Reconstitution, & Storage
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
Stability And Storage |
-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Validation Images
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Cynomolgus ULBP-2 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
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Loaded Human NKG2D, hFc Tag (Cat. NKG-HM22D) on ProA-Biosensor can bind Cynomolgus ULBP-2, His Tag with an affinity constant of 30.00 nM as determined in BLI assay . |
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The purity of Cynomolgus ULBP-2 is greater than 95% as determined by SEC-HPLC. |
Other Available Proteins:
Finding available proteins...
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