Product Description |
Recombinant Human CXCR5 Protein-Nanodisc is expressed from HEK293 with His tag at the C-terminus (FITC-equivalent protein is fused on cytoplasmic part).It contains Met1-Phe372. |
Product Background |
CXCR5 is a serpentine receptor implicated in cell migration in lymphocytes and differentiation in leukocytes. It causes MAPK pathway activation and has known membrane partners for signaling. CXCR5 is also expressed in HL-60 cells, a human acute myeloid leukemia line, following treatment with all-trans retinoic acid, which induces differentiation toward a neutrophil-like state. CXCR5 is necessary for this process; differentiation was crippled in CXCR5 knockout cells and enhanced in cells ectopically expressing it. |
Product Category |
Recombinant Protein / Antibody discovery / Multiple transmembrane proteins / Nanodisc |
Protein |
CXCR5 |
Synonyms |
CXC-R5; CXCR-5; MDR-15; MDR15; CD185; BLR1 |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Met1-Phe372 |
Molecular Weight |
The protein has a predicted MW of 43.3 kDa. |
Activity |
Immobilized Human CXCR5 Nanodisc, His Tag at 5ug/ml(100ul/well) on the plate. Dose response curve for Anti-CXCR5 Antibody, hFc Tag with the EC50 of 11.7ng/ml determined by ELISA (QC Test). See testing image for detail. |
Product Tag |
C-His |
Expression System |
HEK293 |
Endotoxin |
Less than 1 EU per ug by the LAL method. |
Form |
Liquid |
Shipping |
Shipped with dry ice. |
Formulation |
Supplied as 0.22 um filtered solution in PBS (pH 7.4). |
Stability And Storage |
Valid for 6 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
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Immobilized Human CXCR5 Nanodisc, His Tag at 5ug/ml(100ul/well) on the plate. Dose response curve for Anti-CXCR5 Antibody, hFc Tag with the EC50 of 11.7ng/ml determined by ELISA (QC Test). |
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