Human GLP-1R Nanodisc (GLP-HM1N123) Summary
Product Description |
Recombinant Human GLP-1R Nanodisc is expressed from HEK293 with His tag at the C-terminus (FITC-equivalent protein is fused on cytoplasmic part).It contains Met1-Ser463. |
Product Background |
Glucagon-like peptide-1 receptor (GLP-1R) is a critical therapeutic target for type 2 diabetes mellitus (T2DM). GLP-1R emerged as an important pharmacological target for addressing T2DM, as it actively contributes to maintaining glucose homeostasis while promoting both β cell proliferation and insulin release. The impact of GLP-1R agonists such as semaglutide extends beyond diabetes control: they play a multifaceted role in regulating blood glucose levels by reducing hunger, moderating food intake, and managing body weight. Notably, GLP-1R agonists inhibit cancer progression in some malignant tumors. |
Product Category |
Recombinant Protein / Antibody discovery / Multiple transmembrane proteins / Nanodisc |
Human GLP-1R Nanodisc (GLP-HM1N123) Specifications/Details
Protein |
GLP-1R |
Synonyms |
GLP-1 receptor; GLP-1-R; GLP-1R; GLP1R |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Met1-Ser463 |
Molecular Weight |
The protein has a predicted MW of 80.9 kDa. |
Activity |
Immobilized Human GLP-1R Nanodisc, His Tag at 1ug/ml(100ul/well) on the plate. Dose response curve for Anti-GLP-1R Antibody, hFc Tag with the EC50 of 40.2ng/ml determined by ELISA. See testing image for detail. |
Product Tag |
C-His |
Expression System |
HEK293 |
Endotoxin |
Less than 1 EU per ug by the LAL method. |
Form |
Liquid |
Shipping |
Shipped with dry ice. |
Formulation |
Supplied as 0.22 um filtered solution in PBS (pH 7.4). |
Stability And Storage |
Valid for 6 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
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Immobilized Human GLP-1R Nanodisc, His Tag at 1ug/ml(100ul/well) on the plate. Dose response curve for Anti-GLP-1R Antibody, hFc Tag with the EC50 of 40.2ng/ml determined by ELISA. |
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