• Express System: HEK293
  • Product Tag: C-His
  • Activity: Immobilized Human GLP-1R Nanodisc, His Tag at 1ug/ml(100ul/well) on the plate. Dose response curve for Anti-GLP-1R Antibody, hFc Tag with the EC50 of 40.2ng/ml determined by ELISA.
  • Amino Acid Range: Met1-Ser463
Catalog #GLP-HM1N123
Price
Regular price $2,06250
Regular price Sale price $2,06250
/
Size
Avantor VWR Fisher Scientific

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Human GLP-1R Nanodisc (GLP-HM1N123) Summary

Product Description

 Recombinant Human GLP-1R Nanodisc is expressed from HEK293 with His tag at the C-terminus (FITC-equivalent protein is fused on cytoplasmic part).It contains Met1-Ser463.

Product Background

 Glucagon-like peptide-1 receptor (GLP-1R) is a critical therapeutic target for type 2 diabetes mellitus (T2DM). GLP-1R emerged as an important pharmacological target for addressing T2DM, as it actively contributes to maintaining glucose homeostasis while promoting both β cell proliferation and insulin release. The impact of GLP-1R agonists such as semaglutide extends beyond diabetes control: they play a multifaceted role in regulating blood glucose levels by reducing hunger, moderating food intake, and managing body weight. Notably, GLP-1R agonists inhibit cancer progression in some malignant tumors.

Human GLP-1R Nanodisc (GLP-HM1N123) Specifications/Details

Protein
 GLP-1R
Synonyms
 GLP-1 receptor; GLP-1-R; GLP-1R; GLP1R;GLP1 receptor
Accession
Species
 Human
Biotinylated
 no
Amino Acid Range
 Met1-Ser463
Molecular Weight
 The protein has a predicted MW of 80.9 kDa.
Activity
 Immobilized Human GLP-1R Nanodisc, His Tag at 1ug/ml(100ul/well) on the plate. Dose response curve for Anti-GLP-1R Antibody, hFc Tag with the EC50 of 40.2ng/ml determined by ELISA.
Product Tag
 C-His
Fluorophore
 Unconjugated
Expression System
 HEK293
Endotoxin
 Less than 1 EU per ug by the LAL method.

Shipping, Reconstitution, & Storage

Form
 Liquid
Shipping
 Shipped with dry ice.
Formulation
 Supplied as 0.22 um filtered solution in PBS, 200mM L-arginine (pH 7.4). Notice: Not recommended for flow cytometry in mammalian cells.
Stability And Storage
 Valid for 6 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Validation Images

Immobilized Human GLP-1R Nanodisc, His Tag at 1ug/ml(100ul/well) on the plate. Dose response curve for Anti-GLP-1R Antibody, hFc Tag with the EC50 of 40.2ng/ml determined by ELISA. Immobilized Human GLP-1R Nanodisc, His Tag at 1ug/ml(100ul/well) on the plate. Dose response curve for Anti-GLP-1R Antibody, hFc Tag with the EC50 of 40.2ng/ml determined by ELISA.
Other Available Proteins:
Finding available proteins...