Human 4-1BB Ligand/TNFSF9 Trimer Protein (BBL-HM241)
Human 4-1BB Ligand/TNFSF9 Trimer Protein (BBL-HM241)
Human 4-1BB Ligand/TNFSF9 Trimer Protein (BBL-HM241)
  • Express System: HEK293
  • Product Tag: N-monomeric hFc
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Activity: Immobilized Human 4-1BB, His Tag at 1ug/ml (100ul/Well) on the plate. Dose response curve for Human 4-1BB Ligand Trimer, hFc Tag with the EC50 of 5.4ng/ml determined by ELISA (QC Test). See testing image for detail.
  • Amino Acid Range: Arg71-Glu254
Catalog #BBL-HM241
Regular price $315.00
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Product Description

Recombinant Human 4-1BB Ligand/TNFSF9 Trimer Protein is expressed from HEK293 with monomeric hFc tag at the N-Terminus.It contains Arg71-Glu254.

Product Background

The 4-1BBL is the high affinity ligand of 4-1BB, also known as CD137L or TNFSF9. 4-1BB ligand (4-1BBL) is an inducible molecule present on several APC types, including B cells, macrophages and DCs.4-1BB:4-1BBL pathway seems to amplify the existing costimulatory signals, even if the engagement of 4-1BB in the presence of a strong TCR signaling can induce IL-2 production in a CD28-independent manner.

Product Category

Recombinant Protein / Antibody discovery / Immune checkpoint proteins

Protein

4-1BB Ligand/TNFSF9 Trimer

Synonyms

41BB Ligand; 4-1BB Ligand; 4-1BBL; CD137L; TNFSF9

Accession

Species

Human

Biotinylated

no

Amino Acid Range

Arg71-Glu254

Molecular Weight

The protein has a predicted MW of 84.3 kDa same as Bis-Tris PAGE result.

Activity

Immobilized Human 4-1BB, His Tag at 1ug/ml (100ul/Well) on the plate. Dose response curve for Human 4-1BB Ligand Trimer, hFc Tag with the EC50 of 5.4ng/ml determined by ELISA (QC Test). See testing image for detail.

Product Tag

N-monomeric hFc

Expression System

HEK293

Purity

> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC

Endotoxin

Less than 1EU per ug by the LAL method.
Form
Lyophilized
Shipping
Shipped at ambient temperature.
Formulation
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage
-20 to -80°C for 12 months as supplied from date of receipt.;-80°C for 3 months after reconstitution.;Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Immobilized Human 4-1BB, His Tag at 1ug/ml (100ul/Well) on the plate. Dose response curve for Human 4-1BB Ligand Trimer, hFc Tag with the EC50 of 5.4ng/ml determined by ELISA (QC Test). Immobilized Human 4-1BB, His Tag at 1ug/ml (100ul/Well) on the plate. Dose response curve for Human 4-1BB Ligand Trimer, hFc Tag with the EC50 of 5.4ng/ml determined by ELISA (QC Test).
Human 4-1BB Ligand (Trimer) on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. Human 4-1BB Ligand (Trimer) on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Human 4-1BB Ligand (Trimer) is greater than 95% as determined by SEC-HPLC. The purity of Human 4-1BB Ligand (Trimer) is greater than 95% as determined by SEC-HPLC.

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