Product Description |
Recombinant Human ADAM8 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Ile17-Pro655. |
Product Background |
A Disintegrin And Metalloproteinase (ADAM) proteases constitute a family of multifunctional, membrane-bound proteins with traditional sheddase functions. Their protumorigenic potential has been attributed to both, essential (ADAM10 and ADAM17) and 'dispensable' ADAM proteases (ADAM8, 9, 12, 15, and 19). Of specific interest in this review is the ADAM proteinase ADAM8 that has been identified as a significant player in aggressive malignancies including breast, pancreatic, and brain cancer. |
Product Category |
Recombinant Protein |
Target |
ADAM8 |
Synonyms |
ADAM 8; Ms2; Adam8; CD156a; MGC134985 |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Ile17-Pro655 |
Molecular Weight |
The protein has a predicted MW of 70.9 kDa. The protein migrates to 55-70 kDa based on Bis-Tris PAGE result. |
Activity |
Immobilized Human ADAM8, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-ADAM8 Antibody, hFc Tag with the EC50 of 8.1ng/ml determined by ELISA. See testing image for detail. |
Product Tag |
C-His |
Express System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage |
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
|
|
Immobilized Human ADAM8, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-ADAM8 Antibody, hFc Tag with the EC50 of 8.1ng/ml determined by ELISA. |
|
|
Human ADAM8 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
|
|
The purity of Human ADAM8 is greater than 95% as determined by SEC-HPLC. |
Related Products
Have more questions?
Check out our Frequently Asked Questions page for more details about product specifications, ordering, and shipments.
Contact Us
Recently viewed
