Product Description |
Recombinant Human AGER Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Ala23- Ala344. |
Product Background |
The receptor for advanced glycation end products (AGER) is an oncogenic transmembranous receptor up-regulated in various human cancers. AGER promotes proliferation, migration, and inhibits apoptosis of squamous cervical cancer and might function as a tumor promoter in cervical cancer. Our study provides novel evidence for a potential role of AGER in bridging human papillomavirus (HPV)-induced inflammation and cervical cancer. |
Product Category |
Recombinant Protein / Antibody discovery |
Protein |
AGER |
Synonyms |
AGER; RAGE; SCARJ1 |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Ala23- Ala344 |
Molecular Weight |
The protein has a predicted MW of 35.3 kDa. Due to glycosylation, the protein migrates to 50-60 kDa based on Bis-Tris PAGE result. |
Activity |
The affinity constant of 0.19 uM as determined in SPR assay (Biacore T200). See testing image for detail. |
Product Tag |
C-His |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage |
-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
|
|
Human AGER, His Tag immobilized on CM5 Chip can bind Human HMGB1, His Tag with an affinity constant of 0.19 uM as determined in SPR assay (Biacore T200). |
|
|
Human AGER on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
|
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The purity of Human AGER is greater than 95% as determined by SEC-HPLC. |
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