• Express System: HEK293
  • Product Tag: C-hFc (IgG1)
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Activity: Immobilized Human GDF-2, No Tag (Cat. GDF-HM002) at 1ug/ml (100ul/well) on the plate. Dose response curve for Human ALK-1, hFc Tag with the EC50 of 8.5ng/ml determined by ELISA.
  • Amino Acid Range: Asp22-Gln118
Catalog #ALK-HM201
Price
Regular price $270.00
Regular price Sale price $270.00
/
Size
Avantor VWR Fisher Scientific

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Human ALK-1/ACVRL1 Protein (ALK-HM201) Summary

Product Description

 Recombinant Human ALK-1/ACVRL1 Protein is expressed from HEK293 with hFc (IgG1) tag at the C-terminus.It contains Asp22-Gln118.

Product Background

 Activin receptor-like kinase 1 (ALK1)-mediated endothelial cell signalling in response to bone morphogenetic protein 9 (BMP9) and BMP10 is of significant importance in cardiovascular disease and cancer. Structural analyses reveal a tripartite recognition mechanism that defines BMP9 and BMP10 specificity for ALK1, and predict that crossveinless 2 is not an inhibitor of BMP9, which is confirmed by experimental evidence.

Product Category

 Recombinant Protein / Antibody discovery / ADC targets

Human ALK-1/ACVRL1 Protein (ALK-HM201) Specifications/Details

Protein
 ALK-1/ACVRL1
Synonyms
 ACVRLK1; ORW2; ALK1; ALK-1; EC 2.7.11; HHT; HHT2; SKR3; TSR-I; ACVRL1; Activin RLI;Activin RL1
Accession
Species
 Human
Biotinylated
 no
Amino Acid Range
 Asp22-Gln118
Molecular Weight
 The protein has a predicted MW of 36.65 kDa. Due to glycosylation, the protein migrates to 65-85 kDa based on Bis-Tris PAGE result.
Activity
 Immobilized Human GDF-2, No Tag (Cat. GDF-HM002) at 1ug/ml (100ul/well) on the plate. Dose response curve for Human ALK-1, hFc Tag with the EC50 of 8.5ng/ml determined by ELISA.
Product Tag
 C-hFc (IgG1)

Fluorophore

 Unconjugated
Expression System
 HEK293
Purity
 > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin
 Less than 0.1 EU per ug by the LAL method.

Shipping, Reconstitution, & Storage

Form
 Liquid
Shipping
 Shipped with dry ice.
Formulation
 Supplied as 0.22 um filtered solution in PBS (pH 7.4).
Stability And Storage
 Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Validation Images

Immobilized Human GDF-2, No Tag (Cat. GDF-HM002) at 1ug/ml (100ul/well) on the plate. Dose response curve for Human ALK-1, hFc Tag with the EC50 of 8.5ng/ml determined by ELISA. Immobilized Human GDF-2, No Tag (Cat. GDF-HM002) at 1ug/ml (100ul/well) on the plate. Dose response curve for Human ALK-1, hFc Tag with the EC50 of 8.5ng/ml determined by ELISA.
Human ALK-1 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. Human ALK-1 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Human ALK-1 is greater than 95% as determined by SEC-HPLC. The purity of Human ALK-1 is greater than 95% as determined by SEC-HPLC.
Other Available Proteins:
Finding available proteins...
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