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Human Alpha Synuclein Pre-formed Fibrils/PFF Protein (ALS-HE00F) Summary
Product Description |
Recombinant Human Alpha Synuclein Pre-formed Fibrils/PFF Protein is expressed from E.coli without tag.It contains Met1-Ala140. |
Product Background |
Abnormal forms of α-syn trigger selective and progressive neuronal death through mitochondrial impairment, lysosomal dysfunction, and alteration of calcium homeostasis not only in PD but also in other α-syn-related neurodegenerative disorders such as dementia with Lewy bodies, multiple system atrophy, pure autonomic failure, and REM sleep behavior disorder. |
Product Category |
Recombinant Protein / Antibody discovery / Antibody discovery/Others |
Human Alpha Synuclein Pre-formed Fibrils/PFF Protein (ALS-HE00F) Specifications/Details
Protein |
Alpha Synuclein |
Synonyms |
Alpha-synuclein; NACP; SNCA; PARK1 |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Met1-Ala140 |
Molecular Weight |
The Alpha Synuclein Monomer Protein has a predicted MW of 14.5 kDa. |
Activity |
Immobilized Human Alpha Synuclein PFF, No Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Prasinezumab, hFc Tag with the EC50 of 1.5ng/ml determined by ELISA. |
Product Tag |
No Tag |
Fluorophore |
Unconjugated |
Expression System |
E.coli |
Endotoxin |
Less than 0.1 EU per ug by the LAL method. |
Shipping, Reconstitution, & Storage
Form |
Liquid |
Shipping |
Shipped with dry ice. |
Formulation |
Supplied as 0.22 um filtered solution in PBS (pH 7.4). |
Stability And Storage |
Valid for 12 months from date of receipt when stored at -80°C. |
Validation Images
|
|
Immobilized Human Alpha Synuclein PFF, No Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Prasinezumab, hFc Tag with the EC50 of 1.5ng/ml determined by ELISA. |
|
|
Thioflavin T emission intensity increases progressively over time upon incubation of Alpha Synuclein Monomer with Alpha Synuclein PFF. Fluorescence signals were detected with a microplate reader at an excitation wavelength of 450nm and an emission wavelength of 485nm. |
Other Available Proteins:
Finding available proteins...
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