Human Amyloid Beta 42/Abeta 42 Pre-formed Fibrils Protein (AMB-HE04F)

Express System: E.coli
Product Tag: No Tag
Activity: Immobilized Human Amyloid Beta 42 Pre-formed Fibrils, No Tag at 2ug/ml(100ul/well) on the plate. Dose response curve for Trontinemab, hFc Tag with the EC50 of 0.18ug/ml determined by ELISA.
Amino Acid Range: Asp672-Ala713

Catalog #AMB-HE04F

Price

$420⁰⁰

Size

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Human Amyloid Beta 42/Abeta 42 Pre-formed Fibrils Protein (AMB-HE04F) Summary

Product Description

Recombinant Human Amyloid Beta 42/Abeta 42 Pre-formed Fibrils Protein is expressed from E.coli without tag.It contains Asp672-Ala713.

Product Background

Alzheimeŕs disease is one of the major global health challenges. Neuronal cell dysfunction and death are connected to the self-assembly of the amyloid β peptide (Aβ42) into oligomeric and fibrillar aggregates. The fibril surface can catalyze the formation of toxic oligomers via secondary nucleation. The structure of Aβ42 fibrils has been studied using solid state nuclear magnetic resonance (ss-NMR) spectroscopy, cryo-electron microscopy (cryo-EM) (4, 26), and atomic force microscopy (AFM).

Human Amyloid Beta 42/Abeta 42 Pre-formed Fibrils Protein (AMB-HE04F) Specifications/Details

Protein	Amyloid Beta 42/Abeta 42
Synonyms	Amyloid-beta protein 42; Abeta42; Beta-APP42; Aβ42
Accession	P05067-1
Species	Human
Biotinylated	no
Amino Acid Range	Asp672-Ala713
Molecular Weight	The Amyloid Beta 42 monomer protein has a predicted MW of 4.51 kDa.
Activity	Immobilized Human Amyloid Beta 42 Pre-formed Fibrils, No Tag at 2ug/ml(100ul/well) on the plate. Dose response curve for Trontinemab, hFc Tag with the EC50 of 0.18ug/ml determined by ELISA.
Product Tag	No Tag
Expression System	E.coli
Endotoxin	Less than 0.1 EU per ug by the LAL method.

Shipping, Reconstitution, & Storage

Form	Liquid
Shipping	Shipped with dry ice.
Formulation	Supplied as 0.22 um filtered solution in 10 mM HCl.
Stability And Storage	Valid for 12 months from date of receipt when stored at -80°C. Do not store Pre-formed Fibrils at 4°C.； Recommend to aliquot the Pre-formed Fibrils protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Validation Images

	Immobilized Human Amyloid Beta 42 Pre-formed Fibrils, No Tag at 2ug/ml(100ul/well) on the plate. Dose response curve for Trontinemab, hFc Tag with the EC50 of 0.18ug/ml determined by ELISA.
	Negative-stain transmission electron microscopy (TEM) images of Human Amyloid Beta 42 Pre-formed Fibrils, No Tag. Distinct fibrillar structures are visible in TEM micrographs of this product.