Product Description |
Recombinant Human ANGPTL7/CDT6 Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains GIn27-Pro346. |
Product Background |
Angiopoietin-like 7 (ANGPTL7), also known as Corneal-Derived Transcript 6 (CDT6), is a secreted glycoprotein that is structurally related to the angiopoietins. Members of this protein family contain an N-terminal coiled coil domain and a C-terminal fibrinogen-like domain. ANGPTL7 is expressed in the corneal stroma, trabecular meshwork, and sclera and is elevated in glaucoma aqueous humor. Its production is up‑regulated in trabecular meshwork cells by glucocorticoids and TGF-beta and in cartilage by TNF-alpha. |
Product Category |
Recombinant Protein |
Target |
ANGPTL7 |
Synonyms |
angiopoietin-like 7; Angiopoietin-like factor; ANGPTL7; AngX; CDT6; dJ647M16.1; RP4-647M16.2 |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
GIn27-Pro346 |
Molecular Weight |
The protein has a predicted MW of 63.8 kDa. Due to glycosylation, the protein migrates to 70-80 kDa based on Bis-Tris PAGE result. |
Product Tag |
C-hFc |
Express System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage |
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
|
|
Human ANGPTL7 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
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