Human ANXA2 Protein (ANX-HE102)
  • Express System: E.coli
  • Product Tag: N-His
  • Purity: > 95% as determined by Bis-Tris PAGE;> 90% as determined by HPLC
  • Amino Acid Range: Ser2-Asp339
Catalog #ANX-HE102
Regular price $297.00
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Product Description

Recombinant Human ANXA2 Protein is expressed from E.coli with His tag at the N-terminus.It contains Ser2-Asp339.

Product Background

ANXA2, highly expressed in invasive breast cancer cells, is closely related with poor prognosis, and acts as a molecular switch to EGFR activation. ANXA2 expression is inversely correlated with cell sensitivity to gefitinib. Knockdown of ANXA2 expression in MDA-MB-231 cells increased the gefitinib induced cell death. When ANXA2 was overexpressed in MCF7 cells, the gefitinib induced cell death was decreased. Furthermore, the phosphorylation of ANXA2 at Tyr23 is negatively correlated with the sensitivity of TNBC to gefitinib.

Product Category

Recombinant Protein / Antibody discovery

Protein

ANXA2

Synonyms

Chromobindin-8; Lipocortin II; PAP-IV; ANX2; ANX2L4; CAL1H; LPC2D; ANXA2; Annexin A2; Annexin II; LIP2PAP-IV; LPC2D; LPC2DP36; p36

Accession

Species

Human

Biotinylated

no

Amino Acid Range

Ser2-Asp339

Molecular Weight

The protein has a predicted MW of 39.6 kDa same as Bis-Tris PAGE result.

Product Tag

N-His

Expression System

E.coli

Purity

> 95% as determined by Bis-Tris PAGE;> 90% as determined by HPLC

Endotoxin

Less than 1 EU per ug by the LAL method.
Form
Lyophilized
Shipping
Shipped at ambient temperature.
Formulation
Lyophilized from 0.22 um filtered solution in PBS, 50mM L-arginine, 4mM DTT (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage
-20 to -80°C for 12 months as supplied from date of receipt.;-80°C for 3 months after reconstitution.;Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Human ANXA2 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. Human ANXA2 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Human ANXA2 is greater than 90% as determined by SEC-HPLC. The purity of Human ANXA2 is greater than 90% as determined by SEC-HPLC.

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support@kactusbio.us

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