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Human ANXA2 Protein (ANX-HE102) Summary
Product Description |
Recombinant Human ANXA2 Protein is expressed from E.coli with His tag at the N-terminus.It contains Ser2-Asp339. |
Product Background |
ANXA2, highly expressed in invasive breast cancer cells, is closely related with poor prognosis, and acts as a molecular switch to EGFR activation. ANXA2 expression is inversely correlated with cell sensitivity to gefitinib. Knockdown of ANXA2 expression in MDA-MB-231 cells increased the gefitinib induced cell death. When ANXA2 was overexpressed in MCF7 cells, the gefitinib induced cell death was decreased. Furthermore, the phosphorylation of ANXA2 at Tyr23 is negatively correlated with the sensitivity of TNBC to gefitinib. |
Product Category |
Recombinant Protein / Antibody discovery / Antibody discovery/Others |
Human ANXA2 Protein (ANX-HE102) Specifications/Details
Protein |
ANXA2 |
Synonyms |
Chromobindin-8; Lipocortin II; PAP-IV; ANX2; ANX2L4; CAL1H; LPC2D; ANXA2; Annexin A2; Annexin II; LIP2PAP-IV; LPC2D; LPC2DP36; p36 |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Ser2-Asp339 |
Molecular Weight |
The protein has a predicted MW of 39.6 kDa same as Bis-Tris PAGE result. |
Product Tag |
N-His |
Fluorophore |
Unconjugated |
Expression System |
E.coli |
Purity |
> 95% as determined by Bis-Tris PAGE;> 90% as determined by HPLC |
Endotoxin |
Less than 1 EU per ug by the LAL method. |
Shipping, Reconstitution, & Storage
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22 um filtered solution in PBS, 50mM L-arginine, 4mM DTT (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
Stability And Storage |
-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Validation Images
|
|
Human ANXA2 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
|
|
The purity of Human ANXA2 is greater than 90% as determined by SEC-HPLC. |
Other Available Proteins:
Finding available proteins...
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