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Human APOE2/Apolipoprotein E Protein (APO-HM1E2) Summary
Product Description |
Recombinant Human APOE2/Apolipoprotein E Protein is expressed from HEK293 with His tag at the C-terminus.It contains Lys19-His317(R176C). |
Product Background |
Apolipoprotein E (apoE) is a lipid carrier in both the peripheral and the central nervous systems. Lipid-loaded apoE lipoprotein particles bind to several cell surface receptors to support membrane homeostasis and injury repair in the brain. Considering prevalence and relative risk magnitude, the ε4 allele of the APOE gene is the strongest genetic risk factor for late-onset Alzheimer's disease (AD). |
Product Category |
Recombinant Protein / Antibody discovery / Immune checkpoint proteins |
Human APOE2/Apolipoprotein E Protein (APO-HM1E2) Specifications/Details
Protein |
APOE2/Apolipoprotein E |
Synonyms |
APOE2; APOE; Apo-E |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Lys19-His317(R176C) |
Molecular Weight |
The protein has a predicted MW of 35.28 kDa. Due to glycosylation, the protein migrates to 35-42 kDa based on Bis-Tris PAGE result. |
Product Tag |
C-His |
Fluorophore |
Unconjugated |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1 EU per ug by the LAL method. |
Shipping, Reconstitution, & Storage
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
Stability And Storage |
-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Validation Images
|
|
Human APOE2 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
|
|
The purity of Human APOE2 is greater than 95% as determined by SEC-HPLC. |
Other Available Proteins:
Finding available proteins...
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