Human APOE2/Apolipoprotein E Protein (APO-HM1E2)

  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Activity: The affinity constant of 27.11 nM as determined in SPR assay (Biacore T200). See testing image for detail.
  • Exact Sequence: Lys19-His317(R176C)

Catalog: APO-HM1E2

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Product Description Recombinant Human APOE2/Apolipoprotein E Protein is expressed from HEK293 with His tag at the C-terminus.It contains Lys19-His317(R176C).

Product Background

Apolipoprotein E (apoE) is a lipid carrier in both the peripheral and the central nervous systems. Lipid-loaded apoE lipoprotein particles bind to several cell surface receptors to support membrane homeostasis and injury repair in the brain. Considering prevalence and relative risk magnitude, the ε4 allele of the APOE gene is the strongest genetic risk factor for late-onset Alzheimer's disease (AD).

Product Category

Recombinant Protein

Target

APOE2/Apolipoprotein E

Gene/Protein ID

P02649-1

Species

Human

Exact Sequence

Lys19-His317(R176C)
Molecular Weight The protein has a predicted MW of 35.28 kDa. Due to glycosylation, the protein migrates to 35-42 kDa based on Tris-Bis PAGE result.

Activity

The affinity constant of 27.11 nM as determined in SPR assay (Biacore T200). See testing image for detail.

Product Tag

C-His

Express System

HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Liquid
Shipping Shipped with dry ice.
Formulation Supplied as 0.22 um filtered solution in PBS (pH 7.4).
Stability And Storage Valid for 12 months from date of receipt when stored at -80°C.; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Human TREM2, hFc Tag captured on CM5 Chip via Protein A can bind Human APOE2, His Tag with an affinity constant of 27.11 nM as determined in SPR assay (Biacore T200).
The purity of Human APOE2 is greater than 95% as determined by SEC-HPLC.
Human APOE2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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