Name: Human APOE3/Apolipoprotein E Protein (APO-HM203)
Brand: KactusBio
SKU: APO-HM203-100UG
Price: 270.0 USD
Availability: InStock

Human APOE3/Apolipoprotein E Protein (APO-HM203)

Express System: HEK293
Product Tag: N-hFc
Purity: > 95% as determined by Bis-Tris PAGE
Activity: The affinity constant of 20.24 uM as determined in SPR assay (Biacore T200). See testing image for detail.
Amino Acid Range: Lys19-His317

Catalog #APO-HM203

Size

100UG

500UG

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Product Description	Recombinant Human APOE3/Apolipoprotein E Protein is expressed from HEK293 with hFc tag at the N-Terminus.It contains Lys19-His317.
Product Background	Apolipoprotein E (apoE) is a lipid carrier in both the peripheral and the central nervous systems. Lipid-loaded apoE lipoprotein particles bind to several cell surface receptors to support membrane homeostasis and injury repair in the brain. Considering prevalence and relative risk magnitude, the ε4 allele of the APOE gene is the strongest genetic risk factor for late-onset Alzheimer's disease (AD).
Product Category	Recombinant Protein

Target	APOE3/Apolipoprotein E
Accession	P02649
Species	Human
Biotinylated	no
Amino Acid Range	Lys19-His317
Molecular Weight	The protein has a predicted MW of 59.76 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Bis-Tris PAGE result.
Activity	The affinity constant of 20.24 uM as determined in SPR assay (Biacore T200). See testing image for detail.
Product Tag	N-hFc
Express System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

	Human APOE3, hFc Tag captured on CM5 Chip via Protein A can bind Human TREM2, His Tag with an affinity constant of 20.24 uM as determined in SPR assay (Biacore T200).
	Human APOE3 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

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