Human APOE4/Apolipoprotein E Protein (APO-HM102)
Catalog: APO-HM102
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| Product Description | Recombinant Human APOE4/Apolipoprotein E Protein is expressed from HEK293 with His tag at the N-Terminus.It contains Lys19-His317. |
Product Background |
Apolipoprotein E (apoE) is a lipid carrier in both the peripheral and the central nervous systems. Lipid-loaded apoE lipoprotein particles bind to several cell surface receptors to support membrane homeostasis and injury repair in the brain. Considering prevalence and relative risk magnitude, the ε4 allele of the APOE gene is the strongest genetic risk factor for late-onset Alzheimer's disease (AD). |
Product Category |
Recombinant Protein |
Target |
APOE4/Apolipoprotein E |
Gene/Protein ID |
AAB59397.1 |
Species |
Human |
Exact Sequence |
Lys19-His317 |
| Molecular Weight | The protein has a predicted MW of 34.3 kDa. Due to glycosylation, the protein migrates to 35-40 kDa based on Tris-Bis PAGE result. |
Product Tag |
N-His |
Express System |
HEK293 |
| Purity | > 95% as determined by Tris-Bis PAGE |
| Endotoxin | Less than 1EU per ug by the LAL method. |
| Form | Lyophilized |
| Shipping | Shipped at ambient temperature. |
| Formulation | Lyophilized from 0.22um filtered solution in PBS, 2mM DTT (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
| Stability And Storage | Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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Human APOE4 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. |
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